Topic
Nigella damascena
About: Nigella damascena is a research topic. Over the lifetime, 121 publications have been published within this topic receiving 1390 citations. The topic is also known as: love-in-a-mist & Devil-in-a-bush.
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Patent•
28 Aug 2014
TL;DR: In this paper, a melanocyte differentiation induction inhibitor consisting of Nigella damascena polysaccharides as an active ingredient was proposed. But it was only applied to melanocytes.
Abstract: PROBLEM TO BE SOLVED: To provide a melanocyte differentiation induction inhibitor having the activity to inhibit differentiation induction from a stem cell to a melanocyte.SOLUTION: A melanocyte differentiation induction inhibitor comprises Nigella damascena polysaccharides as an active ingredient.
TL;DR: In spring 2013, a blight was observed on plants of Nigella damascena growing in a nursery on the Agroinnova premises (Grugliasco, northern Italy).
Abstract: In spring 2013, a blight was observed on plants of Nigella damascena growing in a nursery on the Agroinnova premises (Grugliasco, northern Italy). Semi-circular, water-soaked le- sions were visible on leaves and stems. Blighted leaves turned brown, withered, and matted on the surrounding foliage. Eventually, infected plants died. Rhizoctonia solani was con- sistently recovered from infected tissues. Three isolates were successfully anastomosed with R. solani isolate AG 1 (ATCC 58946) (Carling, 1996). Mycelium and micro-sclerotia ob- served in vitro were typical for Type 1-B. The internal tran- scribed spacer (ITS) region of rDNA was amplified using the primers ITS1/ITS4 and sequenced (GenBank Accession No. KF719317). BLASTn analysis (Altschul et al., 1997) of the 498 bp amplicon showed 98% homology with the sequence of R. solani HF678125. For pathogenicity tests, 60 healthy plants of N. damascena were inoculated with wheat kernel cultures (3 g/l) of a single isolate of R. solani. The first symptoms developed 3 days post inoculation. R. solani was constantly reisolated from affected plants. This is the first report of R. solani on N. damascena in Italy.
01 Jan 2017
TL;DR: It was substantiated experimentally that Nigella damascena essential oil has an impact on lipid metabolism on the background of chronic heart failure, acute tween, subchronic vitamin D2 lipid pathologies and blood serum lipoprotein lipase (LPL) activity.
Abstract: Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of pharmacological activity of Nigella damascena essential oil while simulating pathology on laboratory animals. Methods: irritant action – HET-CAM test and DRAIZE-test, acute toxicity, open field test, simulated hypoxia method, swimming with the load, No-way-out and Rotating-rod tests, acute lipid pathology under Tween 80 (tween lipid pathology), vitamin D2 hyperlipidemia, simulated chronic heart failure (CHF). Results and Discussion: Nigella damascena essential oil have low irritant effect along with almost non-toxicity. Nigella oil increase life duration with the presence of hypoxia and endurance while swimming-with-the-load test. Course administration of Nigella oil normalize hormone-mediatore metabolism on the background of acute stress. Course administration of Nigella damascena essential oil normalize lipids on the background of CHF, acute tween and subchronic vitamin D2 hyperlipidemias. Conclusion: stress protective, actoprotective and adaptogene properties of Nigella damascena essential oil was pharmacologically proved. It was substantiated experimentally that Nigella damascena essential oil has an impact on lipid metabolism on the background of chronic heart failure (CHF), acute tween, subchronic vitamin D2 lipid pathologies and blood serum lipoprotein lipase (LPL) activity.
Patent•
08 Feb 2019
TL;DR: In this paper, a method of immunocorrection using extracts of fatty oils from seeds of Nigella damascena and Echinacea purpurea, including reproducing immune deficiency in laboratory rats by administering cyclophosphamide once in a dose of 200 mg/kg per the rat body weight, was described.
Abstract: FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and is intended for immunocorrection. Method of immunocorrection using extracts of fatty oils from seeds of Nigella damascena and Echinacea purpurea, including reproducing immune deficiency in laboratory rats by administering cyclophosphamide once in a dose of 200 mg/kg per the rat body weight on the first day of the experiment with the subsequent correction on the second day of the experiment, is characterized in that the correction of immune deficiency is carried out with a mixture of extracts of fatty oils from seeds of seeds of Nigella damascena and Echinacea purpurea at a volume ratio of 1:1, which is intragastrically administered to the laboratory rat, through a probe, in a dose of 4.6 ml/kg/day daily for 14 days.EFFECT: described method of immunocorrection with a combination of components of the mixture provides a synergetic effect and effective correction of experimental immune deficiency.1 cl, 1 tbl, 1 ex
20 Jun 2020
TL;DR: The effectiveness of the seedling method of cultivation of Nigella damascena – a valuable medicinal plant in the Middle Urals has been studied and the optimal variant allowing to obtain high seed productivity is established.
Abstract: Abstract. Introduction allows not only to expand the range of medicinal plants, but also to reduce the severity of the problem of their import substitution. In 2019, a study was conducted at the “Uralets” agricultural farm, on the collection spot of the Ural state agrarian University, to assess the effectiveness of the seedling method for the introduction of Nigella damascena. The purpose of the research: to study the formation of productivity of Nigella damascena in the Middle Urals. The research objectives were to study the most important aspects of the growth and development of Nigella damascena: phenological phases and their onset dates; dynamics of height and average daily growth, productivity. Method of research. During the experiment all observations and records were made according to generally accepted methods. The scheme of the experiment includes 3 options that differ in the timing of sowing seeds of Nigella damascena for seedlings: I – seeding on March 20th (control); II – seeding on March 30th; III – seeding on April 10th. Results. During the first two to three weeks, after planting seedlings in the open ground, the growth of plants was minimal, its value varied in variants from 0.14 (III variant) to 0.31 (I variant) mm per day. The earliest transition of plants to the generative stage of development was noted in I variant, where the budding phase occurred 9 days earlier than in 2 and 22 days earlier than in III variant. The period of mass flowering lasted until mid-August, single flowering – until the end of September. The largest seeds (weight of 100 seeds – 0.31–0.36 g) were obtained in I var. – 66.48 g/m2, significantly lower than in III variant – 11.16 g/m2. The maximum seed productivity is formed in I variant – 100.57 g/m2, the minimum in III variant – 38.93 g/m2. Scientific novelty. For the first time, the effectiveness of the seedling method of cultivation of Nigella damascena – a valuable medicinal plant in the Middle Urals has been studied. The optimal variant allowing to obtain high seed productivity is established.