Topic
Nitrite
About: Nitrite is a research topic. Over the lifetime, 15425 publications have been published within this topic receiving 484581 citations.
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TL;DR: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid.
Abstract: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid. The extent of blocking depended on the compound nitrosated and on the experimental conditions. Urea and ammonium sulfamate were less effective as blocking agents. The possibility of in vivo formation of carcinogenic N-nitroso compounds from drugs could be lessened by the combination of such drugs with the ascorbic acid.
500 citations
TL;DR: Increasing concentrations of nitrate, nitrite, and molecular oxygen enhanced production of nitrous oxide relative to molecular nitrogen during denitrification in soils, resulting from the sequential synthesis of nitrogenous oxide reductases.
Abstract: Increasing concentrations of nitrate, nitrite, and molecular oxygen enhanced production of nitrous oxide relative to molecular nitrogen during denitrification in soils. Soil acidity interacted with nitrate to increase the ratio of nitrous oxide to molecular nitrogen. In response to anoxic conditions, nitrous oxide production initially increased but nitrous oxide was then consumed, a pattern which resulted from the sequential synthesis of nitrogenous oxide reductases.
498 citations
TL;DR: In this article, an overview of the practical implementation of autotrophic nitrogen removal is presented, and the different nitrogen removal processes are compared in terms of operational conditions and a direction for future work is provided.
498 citations
TL;DR: In this paper, the relative roles of adenosine triphosphate, S-nitrosohemoglobin, and nitrite as effectors were investigated, with evidence that hypoxic RBCs mediate vasodilation by reducing nitrite to nitric oxide (NO) and ATP release.
497 citations
Journal Article•
TL;DR: It is proposed that organic nitrate tolerance involves the oxidation of a critical sulfhydryl in the glyceryl trinitrate "receptor" and this hypothesis is supported by the reversal of both in vitro - and in vivo -induced glycery ltrinitrate tolerance by the disulfide reducing agent, dithiothreitol.
Abstract: Tolerance to the vasodilator activity of organic nitrates appears to involve an alteration in a receptor in vascular smooth muscle. An in vitro model of nitrate tolerance was developed by incubation of rabbit thoracic aorta with organic nitrate at alkaline pH, producing a time- and concentration-dependent decrease in sensitivity to glyceryl trinitrate. Cross-tolerance is observed to all organic nitrates studied but not to nonnitrate vasodilators. When aortic strips are incubated at alkaline pH, nitrite formation is enhanced and tissue SH levels decrease. It s proposed that organic nitrate tolerance involves the oxidation of a critical sulfhydryl in the glyceryl trinitrate "receptor." This hypothesis is supported by the reversal of both in vitro - and in vivo -induced glyceryl trinitrate tolerance by the disulfide reducing agent, dithiothreitol.
495 citations