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Nojirimycin

About: Nojirimycin is a research topic. Over the lifetime, 252 publications have been published within this topic receiving 6854 citations.


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Journal ArticleDOI
Naoki Asano1
TL;DR: The past and current applications of glycosidase inhibitors to agricultural and medical fields and the prospect for new therapeutic applications are reconsidered.
Abstract: About 40 years have passed since the classical glycosidase inhibitor nojirimycin was discovered from the cultured broth of the Streptomyces species. Since then, over 100 glycosidase inhibitors have been isolated from plants and microorganisms. Modifying or blocking biological processes by specific glycosidase inhibitors has revealed the vital functions of glycosidases in living systems. Because enzyme-catalyzed carbohydrate hydrolysis is a biologically widespread process, glycosidase inhibitors have many potential applications as agrochemicals and therapeutic agents. Glycosidases are involved in the biosynthesis of the oligosaccharide chains and quality control mechanisms in the endoplasmic reticulum of the N-linked glycoproteins. Inhibition of these glycosidases can have profound effects on quality control, maturation, transport, and secretion of glycoproteins and can alter cell-cell or cell-virus recognition processes. This principle is the basis for the potential use of glycosidase inhibitors in viral infection, cancer, and genetic disorders. In this review, the past and current applications of glycosidase inhibitors to agricultural and medical fields and the prospect for new therapeutic applications are reconsidered.

671 citations

Journal ArticleDOI
TL;DR: Nojirimycin, an antibiotic produced by several Streptomyces has been shown to be d -gluco-piperidinose (5-amino-5-deoxy- d -glucopyranose) on the basis of chemical and spectroscopic evidence and synthesis.

296 citations

Journal ArticleDOI
TL;DR: It has recently been found that the polyhydroxy-nor-tropane alkaloids possess potent glycosidase inhibitory activities.

256 citations

Journal ArticleDOI
TL;DR: In this paper, a microreview of recent syntheses of polyhydroxylated piperidines is presented, focusing on recent synthesises of azasugars and their analogs.

202 citations

Journal ArticleDOI
TL;DR: Nojirimycin can be used to differentiate between α-glucosidase and exo-α- d -glucanase, and between β-gloucono-1,5-lactone and ex-β- β-d -glugal, and the structural similarity of the two inhibitors is discussed.

189 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20221
20215
20203
20192
20183
20174