Topic
Non-rapid eye movement sleep
About: Non-rapid eye movement sleep is a research topic. Over the lifetime, 8661 publications have been published within this topic receiving 389465 citations. The topic is also known as: NREM.
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TL;DR: A role for MCH in vigilance state regulation in response to changes in energy homeostasis is supported and may relate to a recent report of initial clinical trials with a novel MCH-1 receptor antagonist.
131 citations
TL;DR: The frequency-specific clustering of power maps suggests that distinct generators underlie EEG frequency bands and that basic topographic features appear to be state-independent.
130 citations
TL;DR: The results presented suggest that the processes underlying PLM are most active at the transition from wakefulness to sleep and considerably attenuated during deep NREM sleep and even more during REM sleep.
Abstract: We investigated the characteristics of periodic leg movements (PLM) during nocturnal sleep and wakefulness in 13 drug-free patients presenting with the restless legs syndrome (RLS, n = 9) or with isolated PLM (n = 4). Eight-hour polygraphic sleep recordings included the electromyogram (EMG) of both tibialis anterior muscles. Scoring of leg movements was done according to established criteria for periodic movements in sleep, but movements occurring during episodes of wakefulness were scored as well. Twelve out of 13 patients had PLM during wakefulness, including three subjects not affected by RLS. The frequency of periodic movements in sleep (PMS) per hour of total sleep time was significantly lower than the frequency of PLM (including movements during wakefulness) per hour of polygraphic recording. Movement indices based on PMS alone underestimated the relative frequency of PLM particularly in patients with high amounts of wakefulness (> 20%). All features of PLM clearly differed between sleep stages. Relative frequency of movements, their duration and their arousing effect decreased along the nonrapid eye movement (NREM) sleep stages, whereas the intermovement interval increased. During rapid eye movement (REM) sleep the duration of movements was shortest and the intermovement interval was longest. The results presented suggest that the processes underlying PLM are most active at the transition from wakefulness to sleep and considerably attenuated during deep NREM sleep and even more during REM sleep. We suggest including movements during wakefulness in routine PLM scoring to get a more complete picture of the disturbance.
130 citations
TL;DR: The findings of PANV35 indicate that period and amplitude analysis of NREM sleep yields measures which are both sensitive and stable.
130 citations
01 Jan 2013
TL;DR: It is shown that acute sleep deprivation produces changes in mood such as increased sleepiness, fatigue, and confusion; poor performance on many tasks; and increased likelihood of falling asleep when sedentary.
Abstract: Acute sleep deprivation in humans is defined as wakefulness that is extended as compared with normal (usually understood as 16 h) without naps or other sleep periods It is well known that acute sleep deprivation produces changes in mood such as increased sleepiness, fatigue, and confusion; poor performance on many tasks; and increased likelihood of falling asleep when sedentary Current research has also shown, however, that the effects of sleep loss may be mediated by a number of factors ranging from activity levels to medications to genetic composition
130 citations