Topic
Non-rapid eye movement sleep
About: Non-rapid eye movement sleep is a research topic. Over the lifetime, 8661 publications have been published within this topic receiving 389465 citations. The topic is also known as: NREM.
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TL;DR: The results suggested that the hypnotic effect of jujubosides on normal rats may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotIC effect ofJujuboides.
126 citations
TL;DR: Using bipolar depth recordings, this archetypical cortico-thalamo-cortical sequence could provide the global physiological context for memory consolidation during non-REM sleep.
Abstract: Every night, the human brain produces thousands of downstates and spindles during non-REM sleep Previous studies indicate that spindles originate thalamically and downstates cortically, loosely grouping spindle occurrence However, the mechanisms whereby the thalamus and cortex interact in generating these sleep phenomena remain poorly understood Using bipolar depth recordings, we report here a sequence wherein: (1) convergent cortical downstates lead thalamic downstates; (2) thalamic downstates hyperpolarize thalamic cells, thus triggering spindles; and (3) thalamic spindles are focally projected back to cortex, arriving during the down-to-upstate transition when the cortex replays memories Thalamic intrinsic currents, therefore, may not be continuously available during non-REM sleep, permitting the cortex to control thalamic spindling by inducing downstates This archetypical cortico-thalamo-cortical sequence could provide the global physiological context for memory consolidation during non-REM sleep
125 citations
TL;DR: Sleep spindle alterations are associated with later development of dementia in Parkinson's disease, and thus may serve as an additional marker of cognitive decline in these patients.
125 citations
TL;DR: Patients with major depression who suffered a recurrence of depression had less delta EEG activity at baseline and remission, particularly in the lowest delta frequency band of 0.5-1.0 Hz.
125 citations
TL;DR: The marked 24-h variation of maximum slow-wave activity within NREMS episodes may reflect the level of a homeostatic sleep process.
Abstract: Sleep states and power spectra of the electroencephalogram were determined for consecutive 4-s epochs during 24 h in rats that had been implanted with electrodes under deep pentobarbital anesthesia. The power spectra in non-rapid eye movement sleep (NREMS) showed marked trends: low-frequency activity (0.75-7.0 Hz) declined progressively throughout the 12-h light period (L) and remained low during most of the 12-h dark period (D); high-frequency activity (10.25-25.0 Hz) rose toward the end of L and reached a maximum at the beginning of D. Within a single NREMS episode (duration 0.5-5.0 min), slow-wave activity (0.75-4.0 Hz) increased progressively to a plateau level. The rise was approximated by a saturating exponential function: although the asymptote level of the function showed a prominent 24-h rhythm, the time constant remained relatively stable (approximately 40 s). After short interruptions of NREMS episodes, slow-wave activity rose more steeply than after long interruptions. The marked 24-h variation of maximum slow-wave activity within NREMS episodes may reflect the level of a homeostatic sleep process.
125 citations