Topic
Norbornadiene
About: Norbornadiene is a research topic. Over the lifetime, 2389 publications have been published within this topic receiving 38603 citations.
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TL;DR: The synthesis of a carbovir analogue, (±)-homocarbovir (3) was achieved from norbornadiene (4) in seven steps and 27% overall yield as discussed by the authors.
Abstract: The synthesis of a carbovir analogue, (±)-homocarbovir (3) was achieved from norbornadiene (4) in seven steps and 27% overall yield. This route involves a Meinwald-type rearrangement, an acid-hydrolysis of N-tosyl bicyclic enamine 5, and a Pd(0)-catalyzed coupling reaction.
TL;DR: In this article, an efficient route for the synthesis of norbornadiene-tethered tethered organisms was developed and their intramolecular 1,3-dipolar cycloadditions were found to be highly regio-and stereo-selective.
Abstract: Efficient routes for the synthesis of norbornadiene-tethered
nitrones have been developed and their intramolecular 1,3-dipolar
cycloadditions were found to be highly regio- and stereo-selective.
TL;DR: In this article, a reductive coupling reaction with norbornene and norbornadiene in the presence of triethylborane as reducing agent and a Ni-phosphine catalytic system to provide the secondary alcohols (III and (VI), resp., in a smooth and highly diastereoselective fashion.
Abstract: Aliphatic and aromatic aldehydes (II) and (V) undergo a reductive coupling reaction with norbornene (I) and norbornadiene (IV) in the presence of triethylborane as reducing agent and a Ni—phosphine catalytic system to provide the secondary alcohols (III) and (VI), resp., in a smooth and highly diastereoselective fashion.