Topic
NQS
About: NQS is a research topic. Over the lifetime, 337 publications have been published within this topic receiving 4226 citations.
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Dissertation•
11 Jan 2013
2 citations
Journal Article•
TL;DR: Two simple, specific, accurate, precise, sensitive and cost effectivespectrophotometric methods have been developed and validated for quantification of linagliptin in pure form and pharmaceutical formulations.
Abstract: Two simple, specific, accurate, precise, sensitive and cost effectivespectrophotometric methods have been developed and validated for quantification oflinagliptin in pure form and pharmaceutical formulations. Method A is established onthe computation of absorbance of purple coloured chromogen complex at 463 nmwhich is formed by the condensation reaction of the primary amine group oflinagliptin with vanillin (Schiff base formation). Method B is established oncomputation of absorbance of orange coloured chromogen at 454 nm which is formedby the condensation reaction of the primary amino group of linagliptin with NQS(1,2-naphtho quinine 4- sulphonic acid sodium salt) reagent. Two methods executedlinearity in the concentration range of 2.5-20 µg/ml and 10-90 µg/ml for method Aand B respectively. Linear relationship with good correlation coefficients of 0.998 and0.995 were monitored between absorbance and corresponding concentrations of linagliptin in vanillin and NQS respectively. The limit of detection, limit of quantification, molar absorptivity, sandell’s sensitivity and ring born concentration values were determined for the two spectrophotometric methods. The contemplatedmethods were validated statistically as per ICH guidelines. The reliability of both themethods is further ascertained by performing recovery tests by standard additionmethod. No significant interference was inspected from the excipients commonlyused as pharmaceutical aids with the assay procedure. The contemplated methodswere simple, sensitive, specific and can be successfully employed in routine analysisof linagliptin in pharmaceutical dosage forms.
2 citations
TL;DR: This work unifies Jastrow and stabilizer states into a new exact NQS representation that requires at most M = N − 1 hidden units, illustrating how highly expressive α ⩽ 1 can be and could pave the way for more families of quantum states to be represented exactly by compact NZS.
Abstract: Neural-network quantum states (NQS) have become a powerful tool in many-body physics. Of the numerous possible architectures in which neural-networks can encode amplitudes of quantum states the simplicity of the Restricted Boltzmann Machine (RBM) has proven especially useful for both numerical and analytical studies. In particular devising exact NQS representations for important classes of states, like Jastrow and stabilizer states, has provided useful clues into the strengths and limitations of the RBM based NQS. However, current constructions for a system of $N$ spins generate NQS with $M \sim O(N^2)$ hidden units that are very sparsely connected. This makes them rather atypical NQS compared to those commonly generated by numerical optimisation. Here we focus on compact NQS, denoting NQS with a hidden unit density $\alpha = M/N \leq 1$ but with system-extensive hidden-visible unit connectivity. By unifying Jastrow and stabilizer states we introduce a new exact representation that requires at most $M=N-1$ hidden units, illustrating how highly expressive $\alpha \leq 1$ can be. Owing to their structural similarity to numerical NQS solutions our result provides useful insights and could pave the way for more families of quantum states to be represented exactly by compact NQS.
2 citations
TL;DR: Four simple, sensitive and reproducible spectrophotometric methods were developed for the determination of sulfacetamide (SA) and its pharmaceutical formulation and were successfully validated and estimated in bulk and pharmaceutical formulations.
Abstract: Four simple, sensitive and reproducible spectrophotometric methods (Method A, Method B, Method C and Method D) were developed for the determination of sulfacetamide (SA) and its pharmaceutical formulation Method A was developed based on diaziatation of the SA by sodium nitrite in acidic medium followed by coupling with BM reagent having absorption maximum at 530 nm Method B was developed based on reaction of NQS with primary amine in SA in presence of alkaline medium having maximum absorption at 466nm Method C was based on reaction of primary amine with MBTH in presence of FeCl3 having maximum absorption at 562nm Method D was developed based on reduction of phosphomolybdotungstic acid in presence of alkali medium having an absorption maximum at 760 nm Beers law was obeyed in the range of 1 to 3 g/ml for Method A, 5 to 30 g/ml for Method B, 10 to 50 g/ml for Method C, and 100 to 300 g/ml for Method D These methods were successfully validated and estimated in bulk and pharmaceutical formulations
2 citations
01 Sep 2016
TL;DR: The hybrid model shows significantly higher accuracy than both the state-of-the-art model and the π-model when compared with the device simulation data.
Abstract: The state-of-the-art and π-models for the lateral non-quasi-static (NQS) effect are analyzed. The superiority of the π-model to capture the lateral NQS effect is demonstrated through small-signal simulations of both the models, implemented in Verilog-A. A hybrid model is proposed and a corresponding formulation of the base impedance is obtained. The equation gives the base impedance of the state-of-the-art as well as the π-model under appropriate conditions. The methodology to implement the hybrid model in Verilog-A is discussed. The hybrid model shows significantly higher accuracy than both the state-of-the-art model and the π-model when compared with the device simulation data.
2 citations