Topic
Nuclear DNA
About: Nuclear DNA is a research topic. Over the lifetime, 3933 publications have been published within this topic receiving 185830 citations.
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TL;DR: Control of DNA replication by short-lived, newly synthesized proteins could explain the confinement of major nuclear DNA replication to the S period as well as the temporal order of the synthesis of this DNA in Physarum.
64 citations
64 citations
TL;DR: It is concluded that DNA replication occurs in close association with the nuclear membrane in HeLa cells.
64 citations
TL;DR: Intramolecular heterogeneity of eukaryotic nuclear DNA is shown by main-band and satellite DNAs, and the function of the latter is uncertain, but they migrate more slowly in electrophoresis; this seems to be determined by base composition.
Abstract: Intramolecular heterogeneity of eukaryotic nuclear DNA is shown by main-band and satellite DNAs. The function of the latter is uncertain, but they migrate more slowly in electrophoresis; this seems to be determined by base composition.
64 citations
TL;DR: The saturation and competition experiments indicate that there are separate genes for the two classes of rRNA, with the possible exception of a minor homology between 17-S and 25-S rRNA.
Abstract: DNA-RNA hybridization studies have been performed to determine the amount of rRNA genes present in purified nuclear DNA of Tetrahymena pyriformis cultured under various conditions of growth. It was found that 0.32% of the nuclear DNA isolated from exponentially growing cells hybridizes with an equimolar mixture of 17-S and 25-S rRNA. Nuclear DNA isolated from starved cells and from cells in the stationary growth phase hybridizes 30–40% less with rRNA than the nuclear DNA of the exponentially growing cells. This variation of the amount of rRNA genes to the total amount of nuclear DNA suggests that the replication of the rRNA genes and the rest of the nuclear DNA are under separate controls. With the possible exception of a minor homology between 17-S and 25-S rRNA, the saturation and competition experiments indicate that there are separate genes for the two classes of rRNA.
64 citations