Topic
Nuclear DNA
About: Nuclear DNA is a research topic. Over the lifetime, 3933 publications have been published within this topic receiving 185830 citations.
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TL;DR: Data identify DNase1L2 as an essential and specific regulator of programmed cell death in skin appendages, and demonstrate that the breakdown of nuclear DNA is crucial for establishing the full mechanical stability of hair.
63 citations
TL;DR: TRIB3 emerges as an important guardian of genome integrity through its control of APOBEC3A, which links the A3A DNA mutators to the Rb-BRCA1-ATM network.
63 citations
TL;DR: It is postulated that there are two classes of tRNA in Tetrahymena pyriformis mitochondria; the one, “native” tRNA, is mitochondrial DNA-transcript whose coding specificity is unique to mitochondrial tRNA and the other, termed “imported’ t RNA, is transcribed from the nuclear DNA and probably transported into mitochondria.
63 citations
TL;DR: Changes in structure and composition of chromatin indicate that during S phase chromatin progressively condenses and suggest that the condensation is associated with the efflux of nonhistone proteins from the nucleus.
63 citations
TL;DR: It is concluded that exposure of cells to sodium nitroprusside causes oxidation of mitochondrial deoxynucleotide pools, and that buildup of oxidized bases in mitochondrial DNA initiates cell death.
63 citations