Topic
Nucleophile
About: Nucleophile is a research topic. Over the lifetime, 30898 publications have been published within this topic receiving 602877 citations.
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TL;DR: In this paper, homolytic benzylation of 4-substituted pyridines gives 1,2-diphenylethane and a benzyl-4-substantituted Pyridine in a ratio determined by the nature of the 4substituents.
16 citations
TL;DR: In this article, it was shown that 1-naphthamides bearing chiral 8-substituents may exist as pairs of diastereoisomeric atropisomers.
Abstract: Restricted rotation about the Ar–CO bond means that 1-naphthamides bearing chiral 8-substituents may exist as pairs of diastereoisomeric atropisomers. These atropisomers are formed with good to excellent stereoselectivity for the syn-diastereoisomer by the reaction of 8-formyl-1-naphthamides with organolithiums and Grignard reagents. The reduction of 8-acyl-1-naphthamides also proceeds with syn-selectivity. The product alcohols are prone to lactonisation and also to epimerisation, and some of the apparent diastereoselectivities may be the result of thermodynamic, rather than kinetic, control.
16 citations
TL;DR: The nucleophilic alkenoylation of protected chiral α-oxy and α-amino alkanals by lithiated 1-(p -to-luenesulfonyl)-2-alkenyl carbamates has been studied in this paper.
16 citations
TL;DR: In this paper, the ortho-nitro group was substituted with high selectivity in the presence of anionic nucleophiles for 2-ethoxycarbonyl-3-hydroxy-4,6-dinitrobenzamide in MeCN or DMF.
16 citations
TL;DR: In this article, the synthesis of 2,8-dichloroquinolin-4-amine 4 and 4,5,7-trichloromethane-3-(2-chloroethyl)-2-methylbenzo[h][1,6]naphthyridine 8 as novel class of building blocks was described.
16 citations