Topic
Nucleotidase
About: Nucleotidase is a research topic. Over the lifetime, 1863 publications have been published within this topic receiving 65624 citations. The topic is also known as: nucleotide phosphohydrolase & acid nucleotidase.
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TL;DR: Data indicated a significant role for the enzyme in the control of the levels of adenosine 3’,5’-phosphate present in biological systems, which was very desirable because of the extremely low levels present in most biological materials.
2,056 citations
TL;DR: Recent advances in nucleotide-releasing and purine-converting pathways in the vasculature are summarized, with particular emphasis on the nucleotidases of ecto-nucleoside triphosphate diphosphatase/phosphodiesterase family.
1,070 citations
Journal Article•
TL;DR: Changes in the tissue compartmentation of adenine nucleotides probably play a major role in producing the previously observed increase of cyclic adenosine 39,59-phosphate during electrical stimulation of slices.
Abstract: The content cyclic adenosine 39,59-phosphate in guinea pig cerebral cortex slices increases 20-30-fold after a 5-min exposure to a medium containing 0.05 mM adenosine. A similar increase was observed upon exposure to adenine nucleotides. The effect appeared to be specific for adenine ribose monomers. Methylxanthines (0.5 mM) blocked the effect of adenosine, but the blockade could be surmounted by increasing the adenosine concentration. Mutual potentiation of effects was observed when norepinephrine or histamine was added together with adenosine. Nucleotidase activity was observed in slices and homogenates. While this may be related to the mechanism of the adenosine effect, a direct effect of adenosine on adenyl cyclase or cyclic 39,59-nucleotide phosphodiesterase could not be implicated in homogenates. Changes in the tissue compartmentation of adenine nucleotides probably play a major role in producing the previously observed increase of cyclic adenosine 39,59-phosphate during electrical stimulation of slices.
834 citations
TL;DR: The physiologic metabolic role of the anabolic enzymes is discussed in relation to catabolic pathways, and alternative pathways for nucleoside analogue phosphorylation are surveyed, such as the phosphotransfer capacity of 5'-nucleotidase.
573 citations
563 citations