Optical coherence tomography

About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.

Methods for noninvasive analyte sensing

Abstract: Methods for measuring analyte concentration within a tissue using optical coherence tomography (OCT). Radiation is generated, and a first portion of the radiation is directed to the tissue to generate backscattered radiation. A second portion of the radiation is directed to a reflector to generate reference radiation. The backscattered radiation and the reference radiation is detected to produce an interference signal. The analyte concentration is calculated using the interference signal.

Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study.

Abstract: The fovea, which mediates the excellent visual acuity enjoyed by healthy adults, is characterized by an absence of retinal vasculature, a high density of elongated cone inner and outer segments, and a pit without overlying ganglion cell or inner nuclear layers. The fovea is the last retinal region to reach maturity.1 During the development of the central retina, the fovea forms in a rod-free zone that decreases in diameter as the cone inner segments become more slender, outer segments elongate, and the cones pack tightly together.2,3 A ring of parafoveal vasculature defines a central avascular zone (AZ) and the developing foveal dimple.4,5 The protracted course of central retinal and foveal development continues after birth into early childhood as neural and vascular elements take their proper places.6,7 Knowledge of development of the normal central retina and foveal structure has depended heavily on anatomic studies of the simian retina6,8,9 with fewer observations on the human fovea.2,3 Retinopathy of prematurity (ROP) is known to alter development of the central retina and, even if mild, may be associated with deficits in acuity and visual sensitivity.10–12 However, foveal fine structure in ROP has yet to be studied. So far, imaging the living macula in human subjects with a history of ROP has yielded only coarse information about foveal structure.13 The advent of high-speed, high-resolution retinal imaging enables investigation of the central retina in the living human eye with nearly the same fidelity as traditional histology. New technologies include optical coherence tomography (OCT), in which optical cross-sections with high axial resolution are generated14; Fourier domain OCT, a high-speed, multiplexed version of OCT15,16; and adaptive optics (AO), which overcomes a fundamental limitation on lateral resolution imposed by ocular aberrations.17–19 In combination, these technologies provide the ability to visualize microstructures in the living eye.20,21 We used adaptive optics–Fourier domain optical coherence tomography (AO-FDOCT) to investigate the fine structure of the central retina in subjects with ROP.

Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography

Abstract: We demonstrate that tissue structure, birefringence, and blood flow can be imaged simultaneously by use of techniques of polarization-sensitive optical coherence tomography and phase-resolved optical Doppler tomography An efficient data-acquisition procedure is implemented that optimizes the concurrent processing and display of all three image types Images of in vivo human skin acquired with a high-speed fiber-based system are presented