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Optical coherence tomography

About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.


Papers
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Patent
31 Dec 2003
TL;DR: In this paper, an optical coherence tomography (OCT) system including a polarizing splitter disposed to direct light in an interferometer such that the OCT detector operates in a noise-optimized regime is presented.
Abstract: An optical coherence tomography (OCT) system including a polarizing splitter disposed to direct light in an interferometer such that the OCT detector operates in a noise-optimized regime. When scanning an eye, the system detector simultaneously produces a low-frequency component representing a scanning laser ophthalmoscope-like (SLO-like) image pixel and a high frequency component representing a two-dimensional (2D) OCT en face image pixel of each point. The SLO-like image is unchanging with depth, so that the pixels in each SLO-like image may be quickly realigned with the previous SLO-like image by consulting prominent image features (e.g., vessels) should lateral eye motion shift an OCT en face image during recording. Because of the pixel-to-pixel correspondence between the simultaneous OCT and SLO-like images, the OCT image pixels may be remapped on the fly according to the corresponding SLO-like image pixel remapping to create an undistorted 3D image data set for the scanned region.

140 citations

01 Jan 2006
TL;DR: OCT research in dermatology has undergone significant developments since its first application in 1997 and the rising demand for non-invasive monitoring of skin disorders and treatment outcomes emphasize the need for further advances in the field of non- invasive imaging.

140 citations

Journal ArticleDOI
TL;DR: A schematic model of RGC projections is proposed to explain the pattern of macular loss, including the greater vulnerability of the inferior retinal region, and clinical fdOCT reports include RGC+ and RNFL probability plots combined with VF information.
Abstract: Purpose To better understand the nature of glaucomatous damage, especially to the macula, the inner retinal thickness maps obtained with frequency domain optical coherence tomography (fdOCT) were averaged.

140 citations

Journal ArticleDOI
TL;DR: Adaptive Optic Coherence tomography (AO-OCT) as discussed by the authors is a method that combines adaptive optics and optical coherence to obtain volumetric retinal imaging with high isotropic resolution.
Abstract: In vivo imaging of the human retina with a resolution that allows visualization of cellular structures has proven to be essential to broaden our knowledge about the physiology of this precious and very complex neural tissue that enables the first steps in vision. Many pathologic changes originate from functional and structural alterations on a cellular scale, long before any degradation in vision can be noted. Therefore, it is important to investigate these tissues with a sufficient level of detail in order to better understand associated disease development or the effects of therapeutic intervention. Optical retinal imaging modalities rely on the optical elements of the eye itself (mainly the cornea and lens) to produce retinal images and are therefore affected by the specific arrangement of these elements and possible imperfections in curvature. Thus, aberrations are introduced to the imaging light and image quality is degraded. To compensate for these aberrations, adaptive optics (AO), a technology initially developed in astronomy, has been utilized. However, the axial sectioning provided by retinal AO-based fundus cameras and scanning laser ophthalmoscope instruments is limited to tens of micrometers because of the rather small available numerical aperture of the eye. To overcome this limitation and thus achieve much higher axial sectioning in the order of 2-5µm, AO has been combined with optical coherence tomography (OCT) into AO-OCT. This enabled for the first time in vivo volumetric retinal imaging with high isotropic resolution. This article summarizes the technical aspects of AO-OCT and provides an overview on its various implementations and some of its clinical applications. In addition, latest developments in the field, such as computational AO-OCT and wavefront sensor less AO-OCT, are covered.

139 citations

Journal ArticleDOI
TL;DR: The use of spectroscopic optical coherence tomography to assess hemoglobin oxygen saturation of whole blood is investigated in this article, where the authors propose to use the differential attenuation coefficient to determine the degree of saturation.
Abstract: The use of spectroscopic optical coherence tomography to assess hemoglobin oxygen saturation of whole blood is investigated. We propose to use the differential attenuation coefficient to determine the degree of saturation. Our data show qualitative agreement between the measured differential attenuation coefficients as a function of saturation and predictions based on the oxygen-saturation-dependent absorption and scattering properties of blood.

139 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231,805
20223,557
2021907
20201,074
20191,127
20181,113