Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: In this paper, diffuse-light time-gated imaging with transillumination optical coherence tomography was proposed to obtain submillimeter-resolution imaging of objects hidden in biological tissue.
Abstract: We describe diffuse-light time-gated imaging with transillumination optical coherence tomography. Submillimeter-resolution imaging of objects hidden in thick biological tissue is achieved in cases in which ballistic light is absent by selecting only the early-arriving coherent portion of the diffuse transmitted light. By using a femtosecond laser as a high-power low-coherence light source, we perform high-sensitivity (130-dB dynamic range) optical gating with interferometric heterodyne detection. The dependence of image resolution on coherent photon arrival time is investigated in model scattering media.
126 citations
TL;DR: Optical coherence tomography 3 images and a simple model suggest macular hole formation may be due to a defect in the inner retina with secondary vitreous fluid accumulation into the middle and outer retinal tissue.
Abstract: Optical coherence tomography 3 images and a simple model suggest macular hole formation may be due to a defect in the inner retina with secondary vitreous fluid accumulation into the middle and outer retinal tissue.
126 citations
TL;DR: Novel detector development based on CMOS technology to Fourier domain optical coherence tomography achieves depth profile rates up to 200,000 scans/sec, which allows for dramatic improvement for imaging small retinal details, such as photo-receptors and capillaries.
Abstract: Applying novel detector development based on CMOS technology to Fourier domain optical coherence tomography we achieve depth profile rates up to 200,000 scans/sec. This speed allows for dramatic improvement for imaging small retinal details, such as photo-receptors and capillaries. We demonstrate the impact of this achievable speed to Doppler tomography and discuss advantages as well as short-comings of high speed 3D Doppler imaging of the human retina. Experimental data of 3D static D-FDOCT sets from fovea and nerve head region are shown together with first 4D imaging of retinal capillary flow.
126 citations
TL;DR: Whether optical coherence tomography images of human cartilage can be acquired arthroscopically and whether the resulting images have high correlation with histopathology is investigated.
Abstract: BackgroundOptical coherence tomography is an echograph of infrared light that can yield microscopic cross-sectional images of articular cartilage without removing or damaging the tissue.HypothesisTo determine whether optical coherence tomography images of human cartilage can be acquired arthroscopically and whether the resulting images have high correlation with histopathology.MethodsOptical coherence tomography was configured into an arthroscope and used to image 2 human cadaver knees and 45 cores harvested from 9 osteoarthritic knees. The imaged cartilage was then processed for histological analysis. Optical coherence tomography images and histology were graded using a modified Mankin structural score. Agreement was determined using weighted kappa statistics. Morphometric analysis performed on optical coherence tomography images was correlated with histomorphometric analysis using linear regression.ResultsImaging of the medial and lateral femoral condyles and trochlea was readily accomplished using the ...
126 citations
TL;DR: A micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate is developed.
Abstract: We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.
125 citations