scispace - formally typeset
Search or ask a question
Topic

Optical coherence tomography

About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.


Papers
More filters
Journal ArticleDOI
TL;DR: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin that may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects.
Abstract: Background: Optical coherence tomography (OCT) is a new diagnostic method for tissue characterization. Objective: We investigated normal and pathologic structures in human skin in several locations to evaluate the potential application of this technique to dermatology. Methods: Based on the principle of low-coherence interferometry, cross-sectional images of the human skin can be obtained in vivo with a high spatial resolution of about 15 μm. Within a penetration depth of 0.5 to 1.5 mm, structures of the stratum corneum, the living epidermis, and the papillary dermis can be distinguished. Results: Different layers could be detected that were differentiated by induction of experimental blisters and by comparison with corresponding histologic sections. Furthermore, OCT images of several skin diseases and tumors were obtained. Conclusion: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin. It may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects. (J Am Acad Dermatol 1997;37:958-63.)

429 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used optical coherence tomography (OCT), a new technique for cross-sectional imaging of the retina, to morphologically study eyes with nonexudative and exudative age-related macular degeneration.

428 citations

Journal ArticleDOI
02 Jun 1996
TL;DR: Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are novel techniques for noninvasive biomedical imaging based on low-coherence interferometry.
Abstract: Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are novel techniques for noninvasive biomedical imaging based on low-coherence interferometry. OCT achieves high-spatial resolution ( 100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. The technique of OCM combines the depth-ranging capability of OCT with the micron-scale resolution imaging capability of confocal microscopy to extend the available imaging depth of confocal microscopy up to several hundred micrometers deep in highly scattering tissues. The theoretical and technical bases for OCT and OCM imaging are described. Example OCT images are provided in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. Example OCM images revealing cellular-level microstructure up to several hundred micrometers deep in GI tissue are presented for the first time. The potential applications of OCT and OCM imaging in clinical diagnostic medicine are discussed.

428 citations

Book
15 Apr 2002
TL;DR: In this paper, the authors introduce the physics of light-tissue interaction and the application of light scattering by biological objects in imaging and imaging of tissue and tissue-like phytoplasm.
Abstract: Part 1 Physics of Light-Tissue Interaction - Diagnostical Aspects: Introduction to Light Scattering by Biological Objects Optics of Blood Propagation of Pulses and Photon Density Waves in Turbid Media Coherence Phenomena and Statistical Properties of Multiply Scattered Light Tissue Phantoms. Part 2 Pulse and Frequency-Domain Techniques for Tissue Spectroscopy and Imaging: Time-Resolved Imaging in Diffusive Media Frequency-Domain Techniques for Tissue Spectroscopy and Imaging Monitoring of Brain Activity With Near-Infrared Spectroscopy Signal Quantification and Localization in Tissue Near-Infrared Spectroscopy Time-Resolved Detection of Optoacoustic Profiles for Measurement of Optical Energy Distribution in Tissues. Part 3 Scattering, Fluorescence, and Infrared Fourier Transform Spectroscopy of Tissues: Light Back Scattering Spectroscopy of Epithelial Tissues - Principles and Applications Reflectance and Fluorescence Spectroscopy of Human Skin in Vivo Infrared and Raman Spectroscopy of Human Skin in Vivo Fluorescence Technologies in Biomedical Diagnostics. Part 4 Coherent-Domain Methods for Biological Flows and Tissue Ultrastructure Monitoring: Speckle and Doppler Methods of Blood and Lymph Flow Monitoring Real-Time Imaging of Microstructure and Blood Flows Using Optical Coherence Tomography Speckle Technologies for Monitoring and Imaging of Tissues and Tissue-Like Phantoms Optical Assessment of Tissue Mechanics.

427 citations

Journal ArticleDOI
TL;DR: Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo, capable of imaging optical-absorption contrast as deep as 3 mm in biological tissue.
Abstract: Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45–120μm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be ∼15μm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3mm in biological tissue.

424 citations


Network Information
Related Topics (5)
Retinal
24.4K papers, 718.9K citations
85% related
Lens (optics)
156.4K papers, 1.2M citations
83% related
Glaucoma
31.5K papers, 738.2K citations
82% related
Visual acuity
32K papers, 797.1K citations
82% related
Retina
28K papers, 1.2M citations
81% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231,805
20223,557
2021907
20201,074
20191,127
20181,113