Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: Polarization-sensitive optical coherence tomography (PS-OCT) was used to characterize completely the polarization state of light backscattered from turbid media as discussed by the authors, which has potentially useful applications in biomedical optics by imaging simultaneously the structural properties of turbid biological materials.
Abstract: Polarization-sensitive optical coherence tomography (PS-OCT) was used to characterize completely the polarization state of light backscattered from turbid media. Using a low-coherence light source, one can determine the Stokes parameters of backscattered light as a function of optical path in turbid media. To demonstrate the application of this technique we determined the birefringence and the optical axis in fibrous tissue (rodent muscle) and in vivo rodent skin. PS-OCT has potentially useful applications in biomedical optics by imaging simultaneously the structural properties of turbid biological materials and their effects on the polarization state of backscattered light. This method may also find applications in material science for investigation of polarization properties (e.g., birefringence) in opaque media such as ceramics and crystals.
409 citations
TL;DR: This system, based on a Linnik-type interference microscope, illuminated by a white-light thermal lamp, has the highest resolution demonstrated to date for OCT imaging and realistic volume rendering of structures inside biological tissues is possible.
Abstract: We have built a high-resolution optical coherence tomography (OCT) system, based on a Linnik-type interference microscope, illuminated by a white-light thermal lamp. The extremely short coherence length of the illumination source and the large aperture of the objectives permit resolution close to 1 µm in three dimensions. A parallel detection scheme with a CCD camera provides cross-section x–y image acquisition without scanning at a rate of up to 50 Hz. To our knowledge, our system has the highest resolution demonstrated to date for OCT imaging. With identical resolution in three dimensions, realistic volume rendering of structures inside biological tissues is possible.
409 citations
TL;DR: Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langer's lines, and under different skin hydration states, and suggest surface waves with different driving frequencies represent skin biomechanical properties from different layers in depth.
Abstract: Dynamic optical coherence elastography is used to determine in vivo skin biomechanical properties based on mechanical surface wave propagation. Quantitative Young's moduli are measured on human skin from different sites, orientations, and frequencies. Skin thicknesses, including measurements from different layers, are also measured simultaneously. Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langer's lines, and under different skin hydration states. Results also suggest surface waves with different driving frequencies represent skin biomechanical properties from different layers in depth. With features such as micrometer-scale resolution, noninvasive imaging, and real-time processing from the optical coherence tomography technology, this optical measurement technique has great potential for measuring skin biomechanical properties in dermatology.
408 citations
TL;DR: Pachychoroid pigment epitheliopathy should be suspected in eyes with a characteristic fundus appearance related to choroidal thickening and associated retinal pigment epithelial abnormalities but no history of subretinal fluid, and it should be recognised in patients frequently misdiagnosed to avoid unnecessary diagnostic testing and interventions.
Abstract: Purpose:To report nine cases of pachychoroid pigment epitheliopathy.Methods:An observational case series of nine patients who underwent comprehensive ophthalmic examination, fundus photography, fundus autofluorescence, spectral-domain optical coherence tomography, and enhanced depth imaging optical
407 citations
TL;DR: This work reports on the incorporation of an axicon lens into the sample arm of an interferometer to overcome the trade-off between lateral resolution and focusing depth when conventional optical elements are used.
Abstract: In optical coherence tomography, axial and lateral resolutions are determined by the source coherence length and the numerical aperture of the sampling lens, respectively. Whereas axial resolution can be improved by use of a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. We report on the incorporation of an axicon lens into the sample arm of an interferometer to overcome this limitation. Using an axicon lens with a top angle of 160 degrees , we maintained 10-microm or better lateral resolution over a focusing depth of at least 6 mm. In addition to having high lateral resolution, the focusing spot has an intensity that is approximately constant over a greater depth range than when a conventional lens is used.
406 citations