Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: A random forest classifier is built to segment eight retinal layers in macular cube images acquired by OCT to an accuracy of at least 4.3 microns for any of the nine boundaries, with no difference in the accuracy of the algorithm found between the groups.
Abstract: Optical coherence tomography (OCT) has proven to be an essential imaging modality for ophthalmology and is proving to be very important in neurology OCT enables high resolution imaging of the retina, both at the optic nerve head and the macula Macular retinal layer thicknesses provide useful diagnostic information and have been shown to correlate well with measures of disease severity in several diseases Since manual segmentation of these layers is time consuming and prone to bias, automatic segmentation methods are critical for full utilization of this technology In this work, we build a random forest classifier to segment eight retinal layers in macular cube images acquired by OCT The random forest classifier learns the boundary pixels between layers, producing an accurate probability map for each boundary, which is then processed to finalize the boundaries Using this algorithm, we can accurately segment the entire retina contained in the macular cube to an accuracy of at least 43 microns for any of the nine boundaries Experiments were carried out on both healthy and multiple sclerosis subjects, with no difference in the accuracy of our algorithm found between the groups
286 citations
TL;DR: A new technique, femtosecond transillumination optical coherence tomography, for time-gated imaging of objects embedded in scattering media, derives a fundamental limit on ballistic imaging thickness based on quantum noise considerations.
Abstract: We describe a new technique, femtosecond transillumination optical coherence tomography, for time-gated imaging of objects embedded in scattering media. Time gating is performed with a fiber-optic interferometer with femtosecond pulses and coherent heterodyne detection to achieve a 130-dB dynamic range. A confocal imaging arrangement provides additional spatial discrimination against multiply scattered light. By time gating ballistic photons, we achieve 125-microm-resolution images of absorbing objects in media 27 scattering mean free paths thick. We derive a fundamental limit on ballistic imaging thickness based on quantum noise considerations.
286 citations
TL;DR: A novel swept-laser-based Fourier-domain optical coherence tomography system using an electro-optic phase modulator and elimination of low-frequency noises resulting from dc and autocorrelation terms increased the sensitivity by 20 dB.
Abstract: A novel swept-laser-based Fourier-domain optical coherence tomography system using an electro-optic phase modulator was demonstrated. The imaging range was doubled by cancellation of the mirror image. The elimination of low-frequency noises resulting from dc and autocorrelation terms increased the sensitivity by 20 dB.
284 citations
TL;DR: Color Doppler optical coherence tomography (CDOCT) is demonstrated for the first time in living human subjects for bidirectional blood-flow mapping of retinal vasculature.
Abstract: Noninvasive monitoring of blood flow in retinal microcirculation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration, and glaucoma. Color Doppler optical coherence tomography (CDOCT) is a technique that allows simultaneous micrometer-scale resolution cross-sectional imaging of tissue microstructure and blood flow in living tissues. CDOCT is demonstrated for the first time in living human subjects for bidirectional blood-flow mapping of retinal vasculature.
283 citations
TL;DR: A reconstruction method which overcomes fundamental limitations on Doppler flow mapping associated with both high- and low-speed imaging and is successful in retaining the high velocity resolution of CDOCT while eliminating motion artifact caused by slow image acquisition in samples which exhibit repetitive motion.
Abstract: Color Doppler optical coherence tomography (CDOCT) is a noninvasive technique for simultaneous high spatial resolution (~20 μm) imaging and high velocity resolution (~500 μm/s) imaging flowmetry in living tissues. In this paper, we demonstrate a reconstruction method which overcomes fundamental limitations on Doppler flow mapping associated with both high- and low-speed imaging. This algorithm is successful in retaining the high velocity resolution of CDOCT while eliminating motion artifact caused by slow image acquisition in samples which exhibit repetitive motion. We demonstrate reconstruction of blood flow throughout a beating Xenopus laevis heart and surrounding vasculature using gated CDOCT reconstruction.
283 citations