Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: In this article, an all-solidstate Kerr-lens mode-locked Cr:forsterite laser operating at 1.28 μm is demonstrated as a shortcoherence-length, high-average-power source for optical coherence tomographic (OCT) imaging.
Abstract: An all-solid-state Kerr-lens mode-locked Cr:forsterite laser operating at 1.28 μm is demonstrated as a shortcoherence-length, high-average-power source for optical coherence tomographic (OCT) imaging. We achieve ultrahigh resolution by spectrally broadening the laser pulses, using self-phase modulation in a dispersion-shifted single-mode fiber. OCT imaging with a resolution of 6 μm and a dynamic range of 115 dB is achieved.
266 citations
TL;DR: This review considers how the mechanical properties of tissue are linked with tissue function and pathology, and describes currently prominent optical coherence elastography techniques, with emphasis on the methods of mechanical loading and displacement estimation.
Abstract: In optical coherence elastography, images are formed by mapping a mechanical property of tissue. Such images, known as elastograms, are formed on the microscale, intermediate between that of cells and whole organs. Optical coherence elastography holds great promise for detecting and monitoring the altered mechanical properties that accompany many clinical conditions and pathologies, particularly in cancer, cardiovascular disease and eye disease. In this review, we first consider how the mechanical properties of tissue are linked with tissue function and pathology. We then describe currently prominent optical coherence elastography techniques, with emphasis on the methods of mechanical loading and displacement estimation. We highlight the sensitivity to microstrain deformations at tens of micrometer resolution. Throughout, optical coherence elastography is considered in the context of other elastography methods, mainly ultrasound elastography and magnetic resonance elastography. This context serves to highlight its advantages, early stage of development of applications, and strong prospects for future impact.
264 citations
TL;DR: The possibility of measuring a full Doppler flow depth profile in parallel by use of frequency-domain optical coherence tomography is demonstrated and the method is based on a local phase analysis of the backscattered signal and allows for imaging of bidirectional Dopplers flow.
Abstract: The possibility of measuring a full Doppler flow depth profile in parallel by use of frequency-domain optical coherence tomography is demonstrated. The method is based on a local phase analysis of the backscattered signal and allows for imaging of bidirectional Doppler flow. The Doppler frequency limit is 5 kHz for the presented measurements and is set by half of the frame rate of the CCD detector array. We measured the flow of 0.3‐µm microspheres suspended in distilled water at controlled flow rates and in vitro human blood flow through a 200‐µm capillary with a real-time color-encoded Doppler tomogram rate of 2–3/s.
264 citations
TL;DR: The group index of refraction for both dentin and enamel was measured at 1.50 +/- 0.02 and 1.62−0.02, respectively as mentioned in this paper.
Abstract: Optical coherence tomographic images of human dentin and enamel are obtained by use of polarization-sensitive optical coherence tomography. A birefringence effect in enamel (lambda = 856 nm) and light propagation along dentinal tubules are observed. The group index of refraction for both dentin and enamel was measured at 1.50 +/- 0.02 and 1.62 +/- 0.02, respectively.
262 citations
TL;DR: A variety of different applications of this technique are presented in ocular imaging that are ranging from the anterior to the posterior eye segment and the benefits of the method for imaging different diseases as, e.g., age related macula degeneration or glaucoma is demonstrated.
261 citations