Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: Comparing cross-sectional images of primate retinal morphology obtained by optical coherence tomography with light microscopy to determine the retinal components represented in OCT images demonstrated reproducible patterns ofretinal morphology that corresponded to the location of retinal layers seen on light microscopic overlays.
Abstract: Objective: To compare the cross-sectional images of primate retinal morphology obtained by optical coherence tomography (OCT) with light microscopy to determine the retinal components represented in OCT images. Methods: Laser pulses were delivered to the retina to create small marker lesions in a Macaca mulatta . These lesions were used to align in vivo OCT scans and ex vivum histologic cross sections for image comparison. Results: The OCT images demonstrated reproducible patterns of retinal morphology that corresponded to the location of retinal layers seen on light microscopic overlays. Layers of relative high reflectivity corresponded to horizontally aligned retinal components such as the nerve fiber layer and plexiform layers, as well as to the retinal pigment epithelium and choroid. In contrast, the nuclear layers and the photoreceptor inner and outer segments demonstrated relative low reflectivity by OCT. Conclusions: Retinal morphology and macular OCT imaging correlate well, with alignment of areas of high and low reflectivity to specific retinal and choroidal elements. Resolution of retinal structures by OCT depends on the contrast in relative reflectivity of adjacent structures. Use of this tool will enable expanded study of retinal morphology, both normal and pathologic, as it evolves in vivo.
245 citations
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TL;DR: Advances in high-resolution imaging of the anterior and posterior segment have revealed new in vivo details of anatomic, physiologic, and pathologic data for the practice of ophthalmology, and as the technology develops, SD OCT will continue to provide new insights about ocular structure and disease.
243 citations
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21 Jan 2008TL;DR: In this paper, an imaging probe for imaging mammalian tissues and structures using high-resolution imaging, including high frequency ultrasound and optical coherence tomography, is presented, which uses combined high-frequency ultrasound (IVUS) and optical imaging methods such as OCT.
Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest.
242 citations
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TL;DR: A Fourier domain mode-locked (FDML) laser for ultra-high-speed optical coherence tomography (OCT) imaging of the human retina is demonstrated, demonstrating a speed improvement of approximately10x over typical high-speed OCT systems, paving the way for densely sampled volumetric data sets and new imaging protocols.
Abstract: A Fourier domain mode-locked (FDML) laser at 1050 nm for ultra-high-speed optical coherence tomography (OCT) imaging of the human retina is demonstrated. Achievable performance, physical limitations, design rules, and scaling principles for FDML operation and component choice in this wavelength range are discussed. The fiber-based FDML laser operates at a sweep rate of 236 kHz over a 63 nm tuning range, with 7 mW average output power. Ultra-high-speed retinal imaging is demonstrated at 236,000 axial scans per second. This represents a speed improvement of approximately10x over typical high-speed OCT systems, paving the way for densely sampled volumetric data sets and new imaging protocols.
242 citations