Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: The experimental results show that this OCT system can be effectively applied to the measurement of soft tissues, which are less stable than hard tissues, and Polarization parameters such as diattenuation, birefringence, and orientation of the fast axis can be extracted through decomposition of the measured Jones matrix.
Abstract: Two-dimensional depth-resolved Jones-matrix images of scattering biological tissues were measured with novel double-source double-detector polarization-sensitive optical coherence tomography (OCT). The Jones matrix can be determined in a single scan with this OCT system. The experimental results show that this system can be effectively applied to the measurement of soft tissues, which are less stable than hard tissues. Polarization parameters such as diattenuation, birefringence, and orientation of the fast axis can be extracted through decomposition of the measured Jones matrix. The Jones matrix of thermally treated porcine tendon showed a reduction of birefringence from thermal damage. The Jones matrices of porcine skin and bovine cartilage also revealed that the density and orientation of the collagen fibers in porcine skin and bovine cartilage are not distributed as uniformly as in porcine tendon. Birefringence is sensitive to changes in tissue because it is based on phase contrast.
242 citations
TL;DR: This technique, which employs a pair of CCD cameras to detect the in-phase and quadrature components of the heterodyne signal simultaneously, offers the advantage of phase-drift suppression in interferometric measurement.
Abstract: A two-dimensional heterodyne detection technique based on the frequency-synchronous detection method [Jpn. J. Appl. Phys. 39, 1194 (2000)] is demonstrated for full-field optical coherence tomography. This technique, which employs a pair of CCD cameras to detect the in-phase and quadrature components of the heterodyne signal simultaneously, offers the advantage of phase-drift suppression in interferometric measurement. Horizontal cross-sectional images are acquired at the rate of 100 frames/s in a single longitudinal scan, with a depth interval of 6 microm, making the rapid reconstruction of three-dimensional images possible.
241 citations
TL;DR: In vivo subwavelength-resolution photoacoustic microscopy (SW-PAM) is developed that provides exquisitely high optical-absorption contrast due to nonfluorescent, or fluorescent, endogenous pigments and can resolve subcellular organelles.
Abstract: Optical absorption provides essential biological functional information but cannot be sensed by mainstream optical microscopy technologies directly, which detect fluorescence or scattering and may require undesirable labeling. Here we developed in vivo subwavelength-resolution photoacoustic microscopy (SW-PAM) that provides exquisitely high optical-absorption contrast due to nonfluorescent, or fluorescent, endogenous pigments. Having approached the ultimate diffraction-limited optical resolution, SW-PAM can resolve subcellular organelles. Vasculature and early-stage melanoma were imaged with 12:1 and 17:1 contrasts, respectively, without labeling. SW-PAM along with the scaled-up macroscopy, as the only technology that measures the same contrast origin over such a wide length scale, can potentially accelerate translation from microscopic research to clinical practice.
240 citations
TL;DR: In this article, a high-speed dynamic focus control system based on a microelectromechanical mirror was designed to maintain high transverse resolution over the entire depth scan, which can yield sub-optimal lateral resolution outside the focal zone for deep-imaging OCT systems.
239 citations
TL;DR: The utility and limitations of anterior segment OCT are described, specifically in anterior chamber biometry, corneal pachymetric mapping, angle evaluation and high‐resolution cross‐sectional imaging.
Abstract: Optical coherence tomography (OCT) is being employed more and more often to image pathologies and surgical anatomy within the anterior segment, specifically in anterior chamber biometry, corneal pachymetric mapping, angle evaluation and high-resolution cross-sectional imaging The cross-sectional imaging capability of OCT is similar to ultrasound, but its higher resolution allows OCT to measure and visualize very fine anatomic structures No contact is required In this review, we describe the utility and limitations of anterior segment OCT
239 citations