Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
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TL;DR: Cross-sectional birefringence- and polarization-independent backscatter imaging of laser-induced thermal damage in porcine myocardium in vitro is demonstrated using a polarization-sensitive optical coherence tomography system and it is demonstrated that bireFringence is a more sensitive indicator of thermal damage than is backscattered light.
Abstract: We demonstrate cross-sectional birefringence- and polarization-independent backscatter imaging of laser-induced thermal damage in porcine myocardium in vitro, using a polarization-sensitive optical coherence tomography system. We compare the generated images with histological sections of the tissue and demonstrate that birefringence is a more sensitive indicator of thermal damage than is backscattered light. Loss of birefringence in thermally damaged regions is quantified and shown to have significant contrast with undamaged sections of the tissue. A detailed theoretical analysis of the birefringence measurements is provided, including a calculation of the systematic errors associated with background noise, system imperfections, and tissue dichroism.
221 citations
TL;DR: In this article, the authors compare images from phase-variance optical coherence tomography (PV-OCT) and fluorescein angiography (FA) for normal individuals and patients with age-related macular degeneration (AMD) and diabetic retinopathy.
220 citations
TL;DR: This work presents a framework to enable systematic and automatic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient mu(t) of the tissue, and successfully applies the algorithm to OCT patient data.
Abstract: Optical coherence tomography OCT is rap- idly becoming the method of choice for assessing arterial wall pathology in vivo. Atherosclerotic plaques can be di- agnosed with high accuracy, including measurement of the thickness of fibrous caps, enabling an assessment of the risk of rupture. While the OCT image presents mor- phological information in highly resolved detail, it relies on interpretation of the images by trained readers for the identification of vessel wall components and tissue type. We present a framework to enable systematic and auto- matic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient t of the tis- sue. OCT images of 65 coronary artery segments in vitro, obtained from 14 vessels harvested at autopsy, are ana- lyzed and correlated with histology. Vessel wall compo- nents can be distinguished based on their optical proper- ties: necrotic core and macrophage infiltration exhibit strong attenuation, t10 mm 1 , while calcific and fi- brous tissue have a lower t25mm 1 . The algorithm is successfully applied to OCT patient data, demonstrating that the analysis can be used in a clinical setting and assist diagnostics of vessel wall pathology. © 2010 Society of Photo-
220 citations
TL;DR: The spectral domain OCT became available, a new technique that allowed major improvements particularly regarding image acquisition speed and image resolution, and future studies will address how these major technological advances will impact the use of the OCT in research and clinical practice.
Abstract: Optical coherence tomography (OCT) is a rapid non-contact method that allows in vivo imaging of the retina, optic nerve head and retinal nerve fibre layer (RNFL). Since its introduction in Ophthalmology approximately a decade ago, the use of this technology has disseminated into the clinical practice. OCT has proven to be a useful ancillary tool for assessing retinal diseases because of its capability to provide cross-sectional images of the retina, and also to perform quantitative analysis of retinal morphology. In glaucoma, the OCT represents one of the methods capable of documenting and analysing optic disc and RNFL morphology in attempt to diagnose and monitor glaucomatous optic neuropathy. Recently, the spectral domain OCT became available, a new technique that allowed major improvements particularly regarding image acquisition speed and image resolution. Future studies will address how these major technological advances will impact the use of the OCT in research and clinical practice.
219 citations
TL;DR: The RNFL measured by OCT may be useful as a surrogate marker for assessment of brain atrophy in MS and in MS there was a much weaker, non-significant correlation between RNFL thickness and T1, T2 volume, BPF, %gm and %wm fractions that might have resulted from a pronounced post-inflammatory local optic nerve atrophy.
Abstract: Background
Axonal distribution within the retinal nerve fiber layer (RNFL) measured by optical coherence tomography (OCT) correlates with axonal viability and integrity.
219 citations