Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
Papers published on a yearly basis
Papers
More filters
TL;DR: Anterior segment optical coherence tomography and UBM can both be used for anterior segment measurements and yielded comparable results.
Abstract: Purpose To compare anterior segment parameters using quantitative imaging by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Setting Tertiary-care glaucoma research center. Methods Sixty-three eyes of 63 subjects had anterior segment evaluation by AS-OCT (Visante-Zeiss) and UBM (Paradigm). Central corneal thickness (CCT), anterior chamber depth (ACD) (measured from the central corneal endothelium to the anterior lens capsule), and the peripheral iridocorneal angles (temporal and nasal) were assessed and compared. Results There was an excellent correlation between AS-OCT and UBM measurements for the nasal angle (r = 0.84; P Conclusion Anterior segment optical coherence tomography and UBM can both be used for anterior segment measurements and yielded comparable results.
209 citations
TL;DR: A highperformance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz and sensitivity over a depth range of 2.4 mm are reported, enabling choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroid as well as retinal diseases.
Abstract: Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a highperformance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz, sensitivity of >92 dB over a depth range of 2.4 mm with an optical exposure level of 550 µW, and deep penetration into the choroid. Using these new technologies, we demonstrate comprehensive human retina, optic disc, and choroid imaging in vivo. This advance enables us to view choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroidal as well as retinal diseases.
209 citations
TL;DR: A novel endoscopic optical coherence tomography probe was designed and constructed with a 1.9-mm microelectromechanical system (MEMS) motor that does not require the coupling of a rotational single-mode fiber and has the advantages of having a much smaller diameter and being more flexible than traditional endoscopes.
Abstract: A novel endoscopic optical coherence tomography probe was designed and constructed with a 1.9-mm microelectromechanical system (MEMS) motor. The new MEMS endoscopic probe design eliminates the need to couple the rotational energy from the proximal to the distal end of the probe. Furthermore, the endoscopic probe's sheath and fiber have the advantages of having a much smaller diameter and being more flexible than traditional endoscopes since no reinforcement is needed to couple the rotational torque. At the distal end, a prism mounted on a micromotor deflects the light rays to create a transverse circular-scanning pathway. Because our MEMS scanner does not require the coupling of a rotational single-mode fiber, a high scanning speed is possible while eliminating unstable optical signals caused by nonuniform coupling.
209 citations
TL;DR: A low-coherence reflectometer based on a conventional Michelson interferometer and a novel silicon detector chip with a two-dimensional array of pixels that allows parallel heterodyne detection is presented and acquisition of three-dimensional images with more than 100,000 voxels per scan is demonstrated.
Abstract: A low-coherence reflectometer based on a conventional Michelson interferometer and a novel silicon detector chip with a two-dimensional array of pixels that allows parallel heterodyne detection is presented. We demonstrate acquisition of three-dimensional images with more than 100,000 voxels per scan at a sensitivity of -58 dB and a rate of 6 Hz.
207 citations
TL;DR: A threshold of nerve fiber layer thickness (75μm) was demonstrated, which predicted visual recovery after optic neuritis and may be tracked and correlated with visual function within 12 months of an optics neuritis event.
Abstract: IntroductionOptic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis.MethodsThis prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized after optic neuritis; and correlating retinal nerve fiber layer thickness and visual function.ResultsThe earliest significant inter-eye differences manifested 2-months after optic neuritis, in the temporal retinal nerve fiber layer. Inter-eye comparisons revealed significant retinal nerve fiber layer ...
207 citations