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Optical coherence tomography

About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.


Papers
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Journal ArticleDOI
TL;DR: The current state of research in endoscopic optical coherence tomography (OCT) is reviewed, and the reported utility of the methods in digestive, intravascular, respiratory, urinary and reproductive systems is examined.
Abstract: We review the current state of research in endoscopic optical coherence tomography (OCT). We first survey the range of available endoscopic optical imaging techniques. We then discuss the various OCT-based endoscopic methods that have thus far been developed. We compare the different endoscopic OCT methods in terms of their scan performance. Next, we examine the application range of endoscopic OCT methods. In particular, we look at the reported utility of the methods in digestive, intravascular, respiratory, urinary and reproductive systems. We highlight two additional applications—biopsy procedures and neurosurgery—where sufficiently compact OCT-based endoscopes can have significant clinical impacts.

204 citations

Journal ArticleDOI
TL;DR: Buffered Fourier domain mode-locked (FDML) lasers are demonstrated for dynamic phase-sensitive optical coherence tomography (OCT) and 3D OCT phase microscopy and provide excellent displacement sensitivities at extremely high sweep speeds.
Abstract: Buffered Fourier domain mode-locked (FDML) lasers are demonstrated for dynamic phase-sensitive optical coherence tomography (OCT) and 3D OCT phase microscopy. Systems are operated at sweep speeds of 42, 117, and 370 kHz, and displacement sensitivities of 39, 52, and 102 pm are achieved, respectively. Sensitivities are comparable to spectrometer-based OCT phase microscopy systems, but much faster acquisition speeds are possible. An additional factor of sqrt 2 improvement in noise performance is observed for differential phase measurements, which is important for Doppler OCT. Dynamic measurements of piezoelectric transducer motion and static 3D OCT phase microscopy are demonstrated. Buffered FDML lasers provide excellent displacement sensitivities at extremely high sweep speeds.

203 citations

Journal ArticleDOI
TL;DR: The feasibility of using OCT for assessing atherosclerotic plaque microstructure at resolutions of 4 to 16 micrometer-scale cross-sectional images is demonstrated.
Abstract: Optical coherence tomography (OCT) is a recently developed technology that uses infrared light to generate micrometer-scale cross-sectional images ( Science. 1991;254:1178-1181). We recently demonstrated the feasibility of using OCT for assessing atherosclerotic plaque microstructure ( Circulation. 1996;93:1206-1213) at resolutions of 4 to 16 …

203 citations

Journal ArticleDOI
TL;DR: An instrument capable of obtaining two-dimensional images of subsurface structure in real time with no moving parts is described, based on spectral interferometry and uses an imaging spectrograph to obtain spatially resolved spectra.
Abstract: We describe an instrument capable of obtaining two-dimensional images of subsurface structure in real time with no moving parts. The technique is based on spectral interferometry and uses an imaging spectrograph to obtain spatially resolved spectra. A test sample consisting of microscope coverslips and a Ronchi grating was measured, illustrating the system’s depth resolution of 38 ?m and transverse resolution of at least 12.7 ?m. The technique is readily adaptable to endoscopic delivery as well as three-dimensional real-time image acquisition.

202 citations

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed the situation for partial coherence interferometry (PCI) and optical coherence tomography (OCT) imaging of ocular structures and showed that the minimum distance that can be resolved by PCI and OCT is inversely proportional to the source spectral bandwidth.
Abstract: In nondispersive media, the minimum distance that can be resolved by partial coherence interferometry (PCI) and optical coherence tomography (OCT) is inversely proportional to the source spectral bandwidth. Dispersion tends to increase the signal width and to degrade the resolution. We analyze the situation for PCI ranging and OCT imaging of ocular structures. It can be shown that for each ocular segment an optimum source bandwidth yielding optimum resolution exists. If the resolution is to be improved beyond this point, the group dispersion of the ocular media has to be compensated. With the use of a dispersion compensating element, and employing a broadband superluminescent diode, we demonstrate a resolution of 5 μm in the retina of both a model eye and a human eye in vivo. This is an improvement by a factor of 2-3 as compared to currently used instruments. © 1999 Society of Photo-Optical Instrumentation Engineers.

202 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231,805
20223,557
2021907
20201,074
20191,127
20181,113