Topic
Optical coherence tomography
About: Optical coherence tomography is a research topic. Over the lifetime, 19051 publications have been published within this topic receiving 477433 citations. The topic is also known as: optical coherent tomography.
Papers published on a yearly basis
Papers
More filters
TL;DR: To investigate the influence of scattering, pure phase objects consisting of chromium layers containing steps of approximately 100-200-nm height were imaged and the limit of phase imaging through these layers was at approximately 8-9 mean free path lengths thick (single pass).
Abstract: Differential phase-contrast optical coherence tomography allows one to measure the path-length differences of two transversally separated beams in the nanometer range. We calculate these path-length differences from the phase functions of the interferometric signals. Pure phase objects consisting of chromium layers containing steps of approximately 100–200-nm height were imaged. Phase differences can be measured with a precision of ±2°, corresponding to a path-difference resolution of 2–3 nm. To investigate the influence of scattering, we imaged the phase objects through scattering layers with increasing scattering coefficients. The limit of phase imaging through these layers was at approximately 8–9 mean free path lengths thick (single pass).
184 citations
TL;DR: An ultrahigh-speed axial-line scanning rate of 5 MHz is demonstrated and the axial resolution of 8 microm was achieved without re-calibration of the sweep characteristic owing to the passive nature of the frequency-sweeping mechanism.
Abstract: We introduce a new high-speed Fourier-domain optical coherence tomography (FD-OCT) scheme based on a stretched pulse supercontinuum source. A wide-band short pulse of a supercontinuum source of which output spectrum spanned a wavelength range from 1,200 nm to 1,550 nm was stretched to a long pulse of 70-ns duration by using a dispersive fiber due to the group-velocity dispersion, and it was used directly as frequency-swept light for FD-OCT. The OCT spectral interferogram was acquired in the time domain and converted into the spectral domain by the pre-calibrated time-to-wavelength relation. Using this stretched-pulse OCT (SP-OCT) scheme, we have demonstrated an ultrahigh-speed axial-line scanning rate of 5 MHz. The axial resolution of 8 microm was achieved without re-calibration of the sweep characteristic owing to the passive nature of the frequency-sweeping mechanism.
184 citations
TL;DR: Optical coherence tomography scan artifacts are seen surprisingly frequently, adversely affect retinal thickness measurements in a high proportion of cases, and are diagnosis-dependent.
184 citations
TL;DR: In this paper, the absorption coefficients of phantoms and of hemoglobin and oxygenated hemoglobin with spectroscopic optical coherence tomography (SOCT) were measured and the results suggest that SOCT can provide localized, quantitative oxygenation measurements.
Abstract: The combination of optical coherence tomography and spectroscopy may allow for highly localized, quantitative measurements of tissue spectral properties. We present, for the first time to our knowledge, quantitative measurements of the absorption coefficients of phantoms and of hemoglobin and oxygenated hemoglobin with spectroscopic optical coherence tomography (SOCT). Our results suggest that SOCT will be able to provide localized, quantitative oxygenation measurements.
183 citations
TL;DR: This work has developed a novel CDOCT signal-processing strategy capable of imaging physiological flow rates at 8 frames/s, and features hardware-implemented digital autocorrelation across subsequent scans, permitting us to measure 300-Hz-8-kHz Doppler shifts upon signals of 0.6-MHz bandwidth.
Abstract: Color Doppler optical coherence tomography (CDOCT) is a noninvasive optical imaging technique for micrometer-scale physiological flow mapping simultaneously with morphological optical coherence tomography imaging. We have developed a novel CDOCT signal-processing strategy capable of imaging physiological flow rates at 8 frames/s. Our new strategy features hardware-implemented digital autocorrelation across subsequent scans, permitting us to measure 300-Hz-8-kHz Doppler shifts upon signals of 0.6-MHz bandwidth. The performance of the CDOCT system was demonstrated in a flow phantom and in vivo in Xenopus laevis.
183 citations