Topic
Orexin-A
About: Orexin-A is a research topic. Over the lifetime, 1060 publications have been published within this topic receiving 56713 citations. The topic is also known as: orexin-A & hypocretin-1.
Papers published on a yearly basis
Papers
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TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
5,162 citations
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TL;DR: It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.
2,935 citations
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TL;DR: It is determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2) and this result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for Narcoleptic patients.
2,450 citations
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TL;DR: It is shown that human narcoleptics have an 85%-95% reduction in the number of Hcrt neurons, and the presence of gliosis in the hypocretin cell region is consistent with a degenerative process being the cause of the HcrT cell loss in narcoLEpsy.
1,875 citations
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TL;DR: Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models andHypocretein was undetectable in seven out of nine people with narcoLEpsy, indicating abnormal hypocretIn transmission.
1,623 citations