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Showing papers on "Organomercury Compounds published in 1991"


Journal ArticleDOI
TL;DR: Saccharomyces cerevisiae and Candida albicans were incubated with 0.25, 0.5, or 0.75 micrograms of Hg (as HgCl2) per ml of Nelson's medium in the presence of trace amounts of oxygen at 28 degrees C for 12 days and the contents of organomercury in the system and of elemental mercury released from the media and collected in traps were determined.
Abstract: Saccharomyces cerevisiae and Candida albicans were incubated with 0.25, 0.5, or 0.75 micrograms of Hg (as HgCl2) per ml of Nelson's medium in the presence of trace amounts of oxygen at 28 degrees C for 12 days. Two control media were used, one without added Hg and one without yeast inoculum. Yeast cell growth was estimated after 1, 2, 3, and 8 days of incubation. The contents of organomercury in the system and of elemental mercury released from the media and collected in traps were determined at the end of the experiments. The results were as follows. (i) C. albicans was the more mercury-resistant species, but both yeast species failed to grow in the media containing 0.75 micrograms of Hg per ml. (ii) The amounts of organomercury produced by the two species were proportional to the amount of HgCl2 added to the medium. In all cases C. albicans produced considerably larger amounts of methylmercury than S. cerevisiae. (iii) The amounts of elemental Hg produced were inversely proportional to the HgCl2 level added in the case of S. cerevisiae but were all similar in the case of C. albicans. (iv) Neither organomercury nor elemental Hg was produced in any of the control media.

47 citations


Journal ArticleDOI
Kalipada Pahan1, S. Ray1, R. Gachhui1, J. Chaudhuri1, A. Mandal1 
TL;DR: The author isolated a broad-spectrum Hg-resistant Bacillus pasteurii strain DR{sub 2} which could volatilize different mercury compounds and utilize various aromatic compounds as sole sources of carbon and preferentially utilized benzene in a medium containing both glucose and benzene.
Abstract: Aquatic ecosystems may receive aromatic compounds through various routes These compounds can cause cancerous diseases in aquatic animals and enhance mutagenicity of the sediments The persistence of aromatic compounds deposited in sediments is affected by microbial degradation Plasmid-determined mercuric and organomercurial resistance in microorganisms has also been studied by several workers Utilization of various aromatic compounds as sole sources of carbon by an Hg-resistant bacterial strain has not been reported The author isolated a broad-spectrum Hg-resistant Bacillus pasteurii strain DR{sub 2} which could volatilize different mercury compounds and utilize various aromatic compounds as sole sources of carbon This strain preferentially utilized benzene in a medium containing both glucose and benzene To their knowledge, until recently there has been no report on preferential utilization of other compounds, particularly an aromatic compound to glucose in a mixture

10 citations


Book ChapterDOI
Richard J. Flanagan1
01 Jan 1991
TL;DR: In contrast with many other organometallic compounds, organomercury compounds have been described in which the mercury group is present in the molecule with other reactive functional groups as discussed by the authors.
Abstract: Organomercury chemistry began in 1852 with the synthesis of dimethylmercury by Frankland1. Since that time thousands of organomercurials have been described. One of the most attractive aspects of organomercury chemistry is the wide range of compounds reported in the literature. Organomercury compounds are known in all the major families of organic compounds, and aliphatic, vinylic, aromatic and heterocyclic compounds have been prepared with relative ease. In contrast with many other organometallic compounds, organomercury compounds have been described in which the mercury group is present in the molecule with other reactive functional groups. Mercury substitution is usually compatible with alcohols, ketones, esters, amides, carboxylic acids, aldehydes and most nitrogen containing groups. Since radiopharmaceuticals are usually molecules with complex substitution patterns, it is this special ability of mercury groups to coexist with other functionalities and yet offer enhanced reactivity for halogenation, that makes them so attractive as intermediates in radiopharmaceutical chemistry.

4 citations


Journal ArticleDOI
TL;DR: It is concluded that 6-thioguanine acts as a bidentate ligand, coordinating through the 6thione group and deprotonation of N-7 to display significant activity against L1210 leukemia cells.

3 citations