Organomercury Compounds

About: Organomercury Compounds is a research topic. Over the lifetime, 392 publications have been published within this topic receiving 6465 citations.

Synthesis and Molecular Structure Study of New Organotellurium and Organomercury Compounds Based on 4-Bromonaphthalen-1-amine

Abstract: The new organic derivatives of mercury and tellurium have been prepared by a reaction of 4-bromonaphthalen-1-amine with Hg(CH3COO)2 and further with TeBr4. Reaction of (1-amino-4-bromonaphthalen-2-yl)mercury(II) chloride with benzaldehyde then TeBr4 has produced the new aryaltellurium(IV) tribromide containing the azomethine moiety. Reaction of 4-bromo-2-(tribromo-λ4-tellanyl)naphthalen-1-amine with 4-hydroxyphenyl mercury(II) chloride gives asymmetrical diaryaltellurium(IV) dibromide. Reduction of aryaltellurium tribromide and diaryaltellurium dibromide by hydrazine hydrate leads to the corresponding diaryalditelluride and diaryaltullride. Structures of the synthesized compounds have been elucidated from FT-IR, 1H, and 13C NMR spectra. The molecular structures and energies for the compounds were also calculated according to the DFT concept.

Mercuration and Telluration of 2-Fluoro-5-nitroaniline: Synthesis, Antibacterial, and Computational Study

Abstract: New derivatives of organotellurium and organomercury compounds have been synthesized in the reaction of 2-fluoro-5-nitroaniline with mercuric acetate and further with tellurium(IV) tetrabromide Reaction of (4-amino-5-fluoro-2-nitrophenyl)tellurium(IV) tribromide with 4-hydroxyphenyl mercury(II) chloride gives asymmetrical diaryltellurium(IV) dibromide, whereas reaction of (4-amino-5-fluoro-2-nitrophenyl)mercury(II) chloride with phenol and 4-hydroxy benzaldehyde produces a new aryl mercury(II) chloride that contains the azomethine and azo groups Reaction of aryl mercury(II) chloride with tellurium(IV) tetrabromide results in aryaltellurium(IV) tribromide furnished by the azomethine and azo groups Reduction of unsymmetrical diaryltellurium(IV) dibromide and aryltellurium(IV) tribromide by hydrazine hydrate leads to the corresponding asymmetrical diaryltelluride and diarylditelluride Structures of the new synthesized compounds are supported by FT-IR and 1H NMR spectra Anti-bacterial activity of the new products has been tested against Klebsiella pneumonia Proteus, Escherichia coli, Pseudomonas spp, and Staphylococcus aureus The compounds are characterized as highly active The molecular structure level and energies of compounds have been computed through the Density Functional Theory (DFT)

The Bacteriological Evaluation of Some New Water Soluble Organomercury Compounds

Abstract: The therapeutic use of organo-mercury compounds as bactericides is dependent in large measure on their solubility in water and their toxicity. Two methods for increasing the solubility of such compounds have been used. Introduction of acidor nitrogen-containiing groups gives increased solubility, but the former cause a loss of germicidal action and the latter give products having much greater toxicity than the acid derivatives. Neither of these procedures has therefore given a satisfactory solution to the problem. A chemical combination which would produce increased water solubility and lower toxicity would do much toward bettering the application of organo-mercury compounds in the therapeutic field. In 1922 Kharasch2 developed a method whereby organometallic compounds can be made soluble by condensing them with mercapto-carboxylic or sulfonic acids. When mercurials of the type RHgX, where X is an inorganic radical, react with a mercapto acid, HSR' where R' is a group