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Origanum rotundifolium

About: Origanum rotundifolium is a research topic. Over the lifetime, 11 publications have been published within this topic receiving 211 citations.

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Journal ArticleDOI
TL;DR: Globoidnan A (6) has the most antioxidant effects on all assays and could be a promising anticancer agent in Origanum rotundifolium Boiss.
Abstract: Context: Origanum (Lamiaceae) has been used in food and pharmaceutical industries.Objective: Isolation and identification of bioactive compounds from Origanum rotundifolium Boiss. and investigation of their antiproliferative and antioxidant activities.Materials and methods: The aerial part of O. rotundifolium was dried and powdered (1.0 kg ±2.0 g) then extracted with hexane, ethyl acetate, methanol and water. Solvent (3 × 1 L) was used for each extraction for a week at room temperature. The aqueous extract was partitioned with ethyl acetate (3 × 1 L) to yield the water/EtOAc extract subjected to chromatography to isolate the active compounds. The structures of isolated compounds were elucidated by 1 D, 2 D NMR and LC-TOF/MS.Results: Apigenin (1), ferulic acid (2), vitexin (3), caprolactam (4), rosmarinic acid (5), and globoidnan A (6) were isolated and identified. Globoidnan A (6), vitexin (3), and rosmarinic acid (5) revealed the excellent DPPH• scavenging effect with IC50 values of 22.4, 31.4, 4...

63 citations

Journal Article
TL;DR: The essential oils of oregano and thyme may be considered a potential source of a natural antimicrobial for the food industry after testing the toxic and irritating effects on humans.
Abstract: The aim of this study is to investigate in-vitro antimicrobial effects of the essential oils from oregano (Origanum acutidens and Origanum rotundifolium) and thyme (Thymus sipyleus subsp. sipyleus var. rosulans). The chemical composition and antimicrobial attributes of the essential oils obtained from the aerial parts of the plants, of which there were 3 Lamiaceae species, have been studied. A total of 43 microorganisms, including 26 bacteria, 14 fungi, and 3 yeasts species, have been studied by using disc-diffusion (DD) and minimal inhibition concentration (MIC) methods. Mean inhibition zones and MIC values of bacterial strains varied from 8 and 72 mm to 7.8 and 500 µg mL-1, respectively. The maximal inhibition zones and MIC values of the yeast and fungi species sensitive to the essential oils were 8-74 mm and 7.8-500 µg mL-1, respectively. The susceptibility of the tested microorganisms varied depending on the essential oil composition. In general, the essential oils showed higher DD values than tested antibiotics. The essential oils of oregano and thyme may be considered a potential source of a natural antimicrobial for the food industry after testing the toxic and irritating effects on humans.

58 citations

Journal ArticleDOI
TL;DR: The methanol-soluble extract which contains the most polar phytochemicals showed the strongest antioxidant effect in all test systems, and amount of the total phenolics and flavonoids was very high in methanolate extract.
Abstract: This study is designed to examine the chemical composition and in vitroantioxidant activity of the essential oil and various extracts of Origanum rotundifolium Boiss. from Turkey. The total of the 40 identified components accounted for 97.23% (GC) and 95.10% (FID) of the total oil. Major components of the oil were borneol, terpinen-4-ol, and spathulenol. To determine the presence of well known and widespread phenolic compounds, water-soluble extract of O. rotundifolium was analyzed by HPLC. In the methanol-soluble extract, caffeic acid,p-coumaric acid, (+)-catechin, and ferulic acid were found in several quantities. Antioxidant activity of the essential oil and extracts of O. rotundifolium has been determined by four different test systems namely DPPH, b-carotene/linoleic acid, chelating effect and reducing power. A strong correlation was observed between the radical scavenging capacity and polarity of the extracts. The methanol-soluble extract which contains the most polar phytochemicals showed the strongest antioxidant effect in all test systems. As expected, amount of the total phenolics and flavonoids was very high in methanol-soluble extract. Key words: Origanum rotundifolium, extract, essential oil, antioxidant activity, HPLC.

41 citations

01 Jan 2011
TL;DR: Four different concentrations of the essential oils obtained from eleven plant species showed an insecticidal effect on adults of Sitophilus granarius in comparison with controls, and S. hortensis was established to the highest mortality rate in S. granarius but essential oils of S. numerosa and sclarea had no effect.
Abstract: Four different concentrations of the essential oils obtained from eleven plant species (Origanum onites L., Origanum rotundifolium Boiss., Rosmarinus officinalis L., Salvia hydrangea Dc., Salvia numerosa L., Salvia multicaulis Vahl., Salvia sclarea L., Satureja hortensis L., Satureja spicigera (C. Koch) Boiss., Thymus fallax Fisch. & Mey. and Thymus sipyleus Boiss.(Lamiaceae) were tested against adults of Sitophilus granarius (L.) on Petri dishes. After exposure, mortality of the adults was determined at 24, 48 and 96 h. The results show that essential oils of O. onites, O. rotundifolium, R. officinalis, S. hydrangea, S. hortensis, S. spicigera, T. fallax and T. sipyleus have an insecticidal effect on adults of S. granarius in comparison with controls. The insecticidal effect was influenced by the doses of the essential oils and the exposure time. Higher doses and longer exposure time resulted in maximum toxicity on S. granarius. Treatment with essentials oils of O. onites, O. rotundifolium, R. officinalis, S. hydrangea, S. hortensis, S. spicigera, T. fallax and T. sipyleus leads to a higher and S. multicaulis to less mortality of adults of S. granarius but essential oils of S. numerosa and S. sclarea had no effect. The mortality rates after 96 h of treatment with the maximum dose (20 µl) of essential oils of S. hortensis, O. rotundifolium, O. onites, S. spicigera, R. officinalis, T. fallax T. sipyleus, S. hydrangea, S. multicaulis, S. sclarea and S. numerosa was determined as 100, 96.97, 95.27, 94.27, 93.93, 88.88, 82.82, 67.33, 55.21, 41.76 and 39.73 % for S. granarius, respectively. Separately, the mortality rates after 96 h of treatment with the 1 µl in dose of essential oils of S. hortensis was established to the highest mortality rate in S. granarius with 97.97 %, and 5, 10 and 20 µl in dose of S. hortensis with 100 %.

30 citations

Journal ArticleDOI
TL;DR: In this article, water-distilled essential oil of Origanum rotundifolium was analyzed by GC and GC/MS and cis-Sabinene hydrate (21.53%) was found to be the major component in the oil.
Abstract: Water-distilled essential oil of Origanum rotundifolium was analyzed by GC and GC/MS. cis-Sabinene hydrate (21.53%) was found to be the major component in the oil.

20 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20172
20162
20151
20131
20121
20112