Topic
Orthokeratology
About: Orthokeratology is a research topic. Over the lifetime, 849 publications have been published within this topic receiving 17176 citations. The topic is also known as: corneal reshaping & night lenses.
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TL;DR: Myopia and high myopia estimates from 2000 to 2050 suggest significant increases in prevalences globally, with implications for planning services, including managing and preventing myopia-related ocular complications and vision loss among almost 1 billion people with highMyopia.
2,345 citations
TL;DR: On average, subjects wearing ortho-k lenses had a slower increase in axial elongation by 43% compared with that of subjects wearing single-vision glasses, and younger children tended to have faster axial lengthening and may benefit from early orthi-k treatment.
Abstract: PURPOSE. This single-masked randomized clinical trial aimed to evaluate the effectiveness of orthokeratology (ortho-k) for myopic control. METHODS. A total of 102 eligible subjects, ranging in age from 6 to 10 years, with myopia between 0.50 and 4.00 diopters (D) and astigmatism not more than 1.25D, were randomly assigned to wear ortho-k lenses or single-vision glasses for a period of 2 years. Axial length was measured by intraocular lens calculation by a masked examiner and was performed at the baseline and every 6 months. This study was registered at ClinicalTrials.gov, number NCT00962208. RESULTS. In all, 78 subjects (37 in ortho-k group and 41 in control group) completed the study. The average axial elongation, at the end of 2 years, were 0.36 6 0.24 and 0.63 6 0.26 mm in the ortho-k and control groups, respectively, and were significantly slower in the ortho-k group (P 0.54) but was correlated with the initial age of the subjects (P 1.00D per year) were 65% and 13% in younger (age range: 7‐8 years) and older (age range: 9‐10 years) children, respectively, in the control group and were 20% and 9%, respectively, in the ortho-k group. Five subjects discontinued ortho-k treatment due to adverse events. CONCLUSIONS. On average, subjects wearing ortho-k lenses had a slower increase in axial elongation by 43% compared with that of subjects wearing single-vision glasses. Younger children tended to have faster axial elongation and may benefit from early ortho-k treatment. (ClinicalTrials.gov number, NCT00962208.) (Invest Ophthalmol Vis Sci. 2012;53:7077‐ 7085) DOI:10.1167/iovs.12-10565
524 citations
TL;DR: It is indicated that a range of interventions can significantly reduce myopia progression when compared with single vision spectacle lenses or placebo, and pharmacologic interventions, that is, muscarinic antagonists such as atropine and pirenzepine were effective.
480 citations
TL;DR: There was significant initial corneal flattening in the ortho-k group but no significant relationships were found between changes in Corneal power and changes in axial length and vitreous chamber depth and the relationships with changes of refractive errors, AL and VCD.
Abstract: Purpose: Myopia is a common ocular disorder, and progression of myopia in children is of increasing concern. Modern overnight orthokeratology (ortho-k) is effective for myopic reduction and has been claimed to be effective in slowing the progression of myopia (myopic control) in children, although scientific evidence for this has been lacking. This 2 year pilot study was conducted to determine whether ortho-k can effectively reduce and control myopia in children. Methods: We monitored the growth of axial length (AL) and vitreous chamber depth (VCD) in 35 children (7–12 years of age), undergoing ortho-k treatment and compared the rates of change with 35 children wearing single-vision spectacles from an earlier study (control). For the ortho-k subjects, we also determined the changes in corneal curvature and the relationships with changes of refractive errors, AL and VCD. Results: The baseline spherical equivalent refractive errors (SER), the AL, and VCD of the ortho-k and control subjects were not statisti...
478 citations
TL;DR: Results confirm previous reports of slowed eye growth following corneal reshaping contact lens wear, and also confirm that corneals can slow myopia progression in children.
Abstract: Background/aims: Anecdotal evidence indicates that corneal reshaping contact lenses may slow myopia progression in children. The purpose of this investigation is to determine whether corneal reshaping contact lenses slow eye growth. Methods: Forty subjects were fitted with corneal reshaping contact lenses. All subjects were 8 to 11 years and had between −0.75 D and −4.00 D myopia with less than 1.00 D astigmatism. Subjects were age-matched to a soft contact lens wearer from another myopia control study. A-scan ultrasound was performed at baseline and annually for 2 years. Results: Twenty-eight of 40 (70%) subjects wore corneal reshaping contact lenses for 2 years. The refractive error and axial length were similar between the two groups at baseline. The corneal reshaping group had an annual rate of change in axial lengths that was significantly less than the soft contact lens wearers (mean difference in annual change = 0.16 mm, p = 0.0004). Vitreous chamber depth experienced similar changes (mean difference in annual change = 0.10 mm, p = 0.006). Conclusion: Results confirm previous reports of slowed eye growth following corneal reshaping contact lens wear.
355 citations