Topic
Oxidative stress
About: Oxidative stress is a research topic. Over the lifetime, 86513 publications have been published within this topic receiving 3845790 citations. The topic is also known as: oxydative stress.
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TL;DR: There is no explanation, presently, for iron presence in the nucleus, but it certainly imposes a prooxidant trend that needs to be counterbalanced in some way, and evidence is reviewed that nuclear metallothionein plays a role in this regard.
545 citations
TL;DR: The vulnerability of the body to oxidative stress and diseases is significantly enhanced in a sedentary compared to a physically active lifestyle, which means that the well-known beneficial effects of exercise are due to the capability of exercise to produce increased levels of ROS.
544 citations
TL;DR: There is now substantial evidence that oxidative stress plays an important role in the injurious and inflammatory responses in airways diseases such as asthma and chronic obstructive pulmonary disease and effective antioxidant therapy that has good bioavailability and potency is not available.
544 citations
TL;DR: It is shown that members of the STAT family of transcription factors are activated in fibroblasts and A-431 carcinoma cells in response to H2O2, indicating that the JAK-STAT pathway responds to intracellular ROS and that PDGF uses ROS as a second messenger to regulate STAT activation.
Abstract: Reactive oxygen species (ROS) play an important role in the pathogenesis of many human diseases, including the acute respiratory distress syndrome, Parkinson’s disease, pulmonary fibrosis, and Alzh...
544 citations
TL;DR: Molecular evidence is provided to explain the different life span in males and females thanks to higher expression and activities of Mn-superoxide dismutase and of glutathione peroxidase in females, which behave as double transgenics overexpressing superoxide dismUTase and glutathene, conferring protection against free-radical-mediated damage in aging.
544 citations