Topic
Oxidative stress
About: Oxidative stress is a research topic. Over the lifetime, 86513 publications have been published within this topic receiving 3845790 citations. The topic is also known as: oxydative stress.
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TL;DR: The hepatotoxicity of AgNPs was assessed in the liver of adult zebrafish, and data suggest that oxidative stress and apoptosis are associated with AgNP toxicity in the Liver of adultZebrafish.
466 citations
TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.
466 citations
TL;DR: The toxicity of iron in specific tissues and cell types (liver, macrophages and brain) is illustrated by studies with appropriate cellular and animal models and the prospects for chelation therapy in the treatment and possible prevention of neurodegenerative diseases is reviewed.
465 citations
TL;DR: Analysis of mitochondrial responses in iPSC-derived neural cells from PD patients carrying different mutations provides insight into convergence of cellular disease mechanisms between different familial forms of PD and highlights the importance of oxidative stress and mitochondrial dysfunction in this neurodegenerative disease.
Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic and environmental factors that results in degeneration of the nigrostriatal dopaminergic pathway in the brain. We analyzed neural cells generated from induced pluripotent stem cells (iPSCs) derived from PD patients and presymptomatic individuals carrying mutations in the PINK1 (PTEN-induced putative kinase 1 )a ndLRRK2 (leucine-rich repeat kinase 2) genes, and compared them to those of healthy control subjects. We measured several aspects of mitochondrial responses in the iPSC-derived neural cells including production of reactive oxygen species, mitochondrial respiration, proton leakage, and intraneuronal movement of mitochondria. Cellular vulnerability associated with mitochondrial dysfunction in iPSC-derived neural cells from familial PD patients and at-risk individuals could be rescued with coenzyme Q10, rapamycin, or the LRRK2 kinase inhibitor GW5074. Analysis of mitochondrial responses in iPSCderived neural cells from PD patients carrying different mutations provides insight into convergence of cellular disease mechanisms between different familial forms of PD and highlights the importance of oxidative stress and mitochondrial dysfunction in this neurodegenerative disease.
465 citations
TL;DR: It is demonstrated that PON2 is not associated with high density lipoprotein, has antioxidant properties, and prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL (MM-LDL), and inhibits the ability of MM- LDL to induce monocyte chemotaxis, suggesting that Pon2 possesses antioxidant properties similar to those of PON1 and PON3.
465 citations