Topic
Pathogenic bacteria
About: Pathogenic bacteria is a research topic. Over the lifetime, 6374 publications have been published within this topic receiving 132088 citations. The topic is also known as: bacterial pathogens.
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11 Oct 2001
1,899 citations
TL;DR: Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature.
Abstract: The emergence of multidrug-resistant bacteria is a phenomenon of concern to the clinician and the pharmaceutical industry, as it is the major cause of failure in the treatment of infectious diseases. The most common mechanism of resistance in pathogenic bacteria to antibiotics of the aminoglycoside, beta-lactam (penicillins and cephalosporins), and chloramphenicol types involves the enzymic inactivation of the antibiotic by hydrolysis or by formation of inactive derivatives. Such resistance determinants most probably were acquired by pathogenic bacteria from a pool of resistance genes in other microbial genera, including antibiotic-producing organisms. The resistance gene sequences were subsequently integrated by site-specific recombination into several classes of naturally occurring gene expression cassettes (typically "integrons") and disseminated within the microbial population by a variety of gene transfer mechanisms. Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature.
1,663 citations
Book•
01 Jan 1980
1,472 citations
Book•
01 Jan 1976
TL;DR: Biochemical tests for identification of medical bacteria using X-ray diffraction analysis for the determination of Na6(CO3)(SO4)2, Na2SO4, and Na2CO3 are used.
Abstract: Biochemical Tests for identification of medical bacteria , Biochemical Tests for identification of medical bacteria , کتابخانه دانشگاه علوم پزشکی و خدمات بهداشتی درمانی کرمان
1,344 citations
TL;DR: This review discusses the current knowledge on the molecular mechanisms involved in both types of resistance in bacteria.
Abstract: Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance.
1,331 citations