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Penicillium griseofulvum

About: Penicillium griseofulvum is a research topic. Over the lifetime, 169 publications have been published within this topic receiving 2702 citations.


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Journal ArticleDOI
TL;DR: A novel azaphilone compound, called chlamyphilone, with significant insecticidal activity, has been isolated from the culture filtrate of P. chlamydosporia, and its structure has been determined using extensive spectroscopic methods and chemical derivatization.
Abstract: Metabolites from a collection of selected fungal isolates have been screened for insecticidal activity against the aphid Acyrthosiphon pisum. Crude organic extracts of culture filtrates from six fungal isolates (Paecilomyces lilacinus, Pochonia chlamydosporia, Penicillium griseofulvum, Beauveria bassiana, Metarhizium anisopliae and Talaromyces pinophilus) caused mortality of aphids within 72 h after treatment. In this work, bioassay-guided fractionation has been used to characterize the main bioactive metabolites accumulated in fungal extracts. Leucinostatins A, B and D represent the bioactive compounds produced by P. lilacinus. From P. griseofulvum and B. bassiana extracts, griseofulvin and beauvericin have been isolated, respectively; 3-O-Methylfunicone and a mixture of destruxins have been found in the active fractions of T. pinophilum and M. anisopliae, respectively. A novel azaphilone compound, we named chlamyphilone, with significant insecticidal activity, has been isolated from the culture filtrate of P. chlamydosporia. Its structure has been determined using extensive spectroscopic methods and chemical derivatization.

11 citations

Journal ArticleDOI
26 May 2020
TL;DR: The aim of this work was to select GCC+ isolates with antifungal activity to study its effectiveness in a dry-cured ham model system at the environmental conditions reached during the ripening, and showed that the inoculation of S. xylosus completely inhibited the growth of most fungi.
Abstract: Toxigenic moulds can develop on the surface of dry-cured meat products during ripening due to their ecological conditions, which constitutes a risk for consumers. A promising strategy to control this hazard is the use of antifungal microorganisms usually found in these foods. However, to date, the effectiveness of gram-positive catalase-positive cocci (GCC+) has not been explored. The aim of this work was to select GCC+ isolates with antifungal activity to study its effectiveness in a dry-cured ham model system at the environmental conditions reached during the ripening. Forty-five strains of GCC+ were evaluated and the isolate Staphylococcus xylosus Sx8 was selected to assess its efficacy at two different concentrations (106 and 104 cfu/mL) against Penicillium nordicum, Aspergillus flavus, Aspergillus parasiticus, and Penicillium griseofulvum at 15, 20, and 25 °C. The results showed that the inoculation of 106 cfu/mL of S. xylosus completely inhibited the growth of most fungi. In addition, in the presence of this strain at 104 cfu/mL, a significant reduction in fungal growth and mycotoxins production was observed at the three temperatures studied. In conclusion, S. xylosus Sx8 possesses great potential as a biological agent to control toxigenic moulds in dry-cured meat products.

11 citations

Journal ArticleDOI
02 Apr 1960-Nature
TL;DR: The isolation and identification of shikimic acid and related substances are described, which is interesting because of its possible conversion to phenolic substances such as has been shown for Escherichia coli.
Abstract: SEVERAL phenolic substances have been isolated from the cultures of Penicillium griseofulvum Dierckx: 2-hydroxy-6-methylbenzoic acid1, 2,5-dihydroxybenzoic acid2, o-, m- and p-hydroxybenzoic acid3, 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid and 3,5-dihydroxybenzoic acid4. Those compounds, together with amino-benzoic acids5, fulvic acid6, griseofulvine7 and patuline8, were identified in metabolic solutions of cultures ten days of age or older. In order to detect substances which could be involved in the production of benzoic derivatives it seemed advisable to investigate the metabolic solution in the earliest stages of the culture. This has led to the identification of shikimic acid, which is interesting because of its possible conversion to phenolic substances such as has been shown for Escherichia coli 9. Besides shikimic acid, sedoheptulose, d-erythrose and pyruvic acid have also been found. This communication describes the isolation and identification of shikimic acid and related substances.

11 citations

Journal ArticleDOI
TL;DR: The effects of catabolite repression of initial glucose on the synthesis of α-amylase from Penicillium chrysogenum and Penicilium griseofulvum were investigated under solid-state fermentation (SSF) and submerged fermentation (SmF) systems.
Abstract: The effects of catabolite repression of initial glucose on the synthesis of α-amylase from Penicillium chrysogenum and Penicillium griseofulvum were investigated under solid-state fermentation (SSF) and submerged fermentation (SmF) systems. The results obtained from either fermentation were compared with each other. In the SmF system, initial glucose concentration above 10 mg/mL completely repressed the production of α-amylase from P. chrysogenum and P. griseofulvum. However, the repression in the SSF system was not complete, even when the glucose level was raised to 160 mg/g.

10 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20214
20207
20198
201811
20176
20167