Topic
Penicillium griseofulvum
About: Penicillium griseofulvum is a research topic. Over the lifetime, 169 publications have been published within this topic receiving 2702 citations.
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TL;DR: Deep-sea viridicatol may represent a novel therapeutic for allergic diseases by alleviating intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice.
Abstract: Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were established to explore the anti-allergic properties of viridicatol. On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-α; and promote the production of interleukin-10 in the serum. The treatment of viridicatol also downregulated the population of B cells and mast cells (MCs), as well as upregulated the population of regulatory T cells in the spleen. Moreover, viridicatol alleviated intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice. Furthermore, the accumulation of Ca2+ in RBL-2H3 cells was significantly suppressed by viridicatol, which could block the activation of MCs. Taken together, these data indicated that deep-sea viridicatol may represent a novel therapeutic for allergic diseases.
10 citations
TL;DR: The identification of this vital gene, which is potentially involved in many cellular functions in pathogenic dermatophyte fungi, is the first step towards understanding the functional characteristics of β-tubulin in such fungi and may help in the development of new antifungal drugs against dermatophytes.
9 citations
TL;DR: GeneWalking has been performed to identify genes both upstream and downstream of the isoepoxydon dehydrogenase (idh) gene, and the first report of an isoamyl alcohol oxidase gene in a species of the genus Penicillium.
Abstract: The genes for the patulin biosynthetic pathway are most likely arranged in a cluster, as is often the case for other mycotoxins. With this in mind, GeneWalking has been performed to identify genes both upstream and downstream of the isoepoxydon dehydrogenase (idh) gene. A gene present in Penicillium griseofulvum NRRL 2159A had high sequence homology to the isoamyl alcohol oxidase (iao) gene and was detected downstream of the idh gene and in the same orientation. By virtue of the presence of a signal peptide sequence, the newly identified gene coded for a secreted protein with an FAD-binding domain and potential for N-glycosylation. An open reading frame consisted of 1946 nucleotides, containing four putative introns and encoding a 22 amino acid signal peptide. The 571 amino acid mature protein contained nine cysteine residues and had 11 potential N-linked glycosylation sites. Searches using GenBank indicated that Aspergillus terreus, A. oryzae, A. fumigatus, and Gibberella zeae contain genes coding for a putative isoamyl alcohol oxidase. When the translated query was compared with the translated database, the highest scores were seen with A. clavatus (E value of 0.00), A. fumigatus (E value of 8e−142), and A. oryzae and A. terreus (each having an E value of 2e−141). Reverse transcription-polymerase chain reaction analysis confirmed that the iao gene was transcribed. The amplified products were sequenced for confirmation of their identities. This is the first report of an isoamyl alcohol oxidase gene in a species of the genus Penicillium.
9 citations
TL;DR: Mycelial dry weight, pH and production of patulin and griseofulvin were assayed in a minimal and a complete medium; patulin or griseefulvin production was ass tested in apple juice.
Abstract: Production of patulin and griseofulvin by a strain of Penicillium griseofulvum is described Mycelial dry weight, pH and production of patulin and griseofulvin were assayed in a minimal and a complete medium; patulin or griseofulvin production was assayed in apple juice
9 citations
TL;DR: A critical review of the literature revealed that only seven other species of Penicillium have been convincingly documented as agents of penicilliosis on the basis of histologic and cultural findings.
Abstract: A sudden fatal illness developed in a group of New World toucanets held captive in Finland. Necropsy studies on one of the birds revealed the presence of invasive, hyaline, septate, branched mycelium in the lungs, air sacs, liver and other tissues. In addition, conidiophores and conidial chains, typical of members of the genus Penicillium were present in the lungs and air sacs. Cultures yielded a mould which was subsequently identified as Penicillium griseofulvum. A critical review of the literature revealed that only seven other species of Penicillium have been convincingly documented as agents of penicilliosis on the basis of histologic and cultural findings.
9 citations