scispace - formally typeset
Search or ask a question
Topic

Perfusion scanning

About: Perfusion scanning is a research topic. Over the lifetime, 9496 publications have been published within this topic receiving 223860 citations. The topic is also known as: perfusion imaging.


Papers
More filters
Journal ArticleDOI
TL;DR: Cardiac hybrid imaging relies on the fusion of anatomical and functional imaging using coronary computed tomography angiography and MPI, respectively, and provides incremental value as compared with either stand-alone modality.
Abstract: Noninvasive assessment of coronary artery disease remains a challenging task, with a large armamentarium of diagnostic modalities. Myocardial perfusion imaging (MPI) is widely used for this purpose whereby cardiac positron emission tomography (PET) is considered the gold standard. Next to relative radiotracer distribution, PET allows for measurement of absolute myocardial blood flow. This quantification of perfusion improves diagnostic accuracy and prognostic value. Cardiac hybrid imaging relies on the fusion of anatomical and functional imaging using coronary computed tomography angiography and MPI, respectively, and provides incremental value as compared with either stand-alone modality.

80 citations

Journal ArticleDOI
TL;DR: Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue, which correlated well by calculating Pearson's correlation coefficients and remained unchanged after stereotactic radiosurgery.
Abstract: Objectives:To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI).Methods:Sixty-two patients with brain metastases were examined on a 1.5

80 citations

Journal ArticleDOI
TL;DR: The results show that patients with chest pain and normal coronary angiograms had significant perfusion responses to adenosine in both the subendocardium and subepicardium, and the index for myocardial perfusion reserve (MPRI) was 1.50.
Abstract: I read with interest the recent article by Vermeltfoort et al , 1 on the use of dynamic contrast enhancement in MRI to evaluate the possible presence of subendocardial ischaemia in patients with chest pain and normal coronary arteries (‘syndrome X’) Their conclusion, that they found no evidence of subendocardial hypoperfusion with adenosine stress in these patients, is in striking contrast to a previous report by Panting et al , 2 who found evidence of a failure of the perfusion of the …

80 citations

Journal ArticleDOI
TL;DR: In this paper, the authors demonstrate the use of OCT/OMAG to image and measure the effects of acute intraocular pressure (IOP) elevation on retinal, choroidal and optic nerve head (ONH) perfusion in the rat eye.
Abstract: In this paper, we demonstrate the use of optical coherence tomography/optical microangiography (OCT/OMAG) to image and measure the effects of acute intraocular pressure (IOP) elevation on retinal, choroidal and optic nerve head (ONH) perfusion in the rat eye. In the experiments, IOP was elevated from 10 to 100 mmHg in 10 mmHg increments. At each IOP level, three-dimensional data volumes were captured using an ultrahigh sensitive (UHS) OMAG scanning protocol for 3D volumetric perfusion imaging, followed by repeated B-scans for Doppler OMAG analysis to determine blood flow velocity. Velocity and vessel diameter measurements were used to calculate blood flow in selected retinal blood vessels. Choroidal perfusion was calculated by determining the peripapillary choroidal filling at each pressure level and calculating this as a percentage of area filling at baseline (10 mmHg). ONH blood perfusion was calculated as the percentage of blood flow area over a segmented ONH area to a depth 150 microns posterior to the choroidal opening. We show that volumetric blood flow reconstructions revealed detailed 3D maps, to the capillary level, of the retinal, choroidal and ONH microvasculature, revealing retinal arterioles, capillaries and veins, the choroidal opening and a consistent presence of the central retinal artery inferior to the ONH. While OCT structural images revealed a reversible compression of the ONH and vasculature with elevated IOP, OMAG successfully documented changes in retinal, choroidal and ONH blood perfusion and allowed quantitative measurements of these changes. Starting from 30 mm Hg, retinal blood flow (RBF) diminished linearly with increasing IOP and was nearly extinguished at 100 mm Hg, with full recovery after return of IOP to baseline. Choroidal filling was unaffected until IOP reached 60 mmHg, then decreased to 20% of baseline at IOP 100 mmHg, and normalized when IOP returned to baseline. A reduction in ONH blood perfusion at higher IOP’s was also observed, but shadow from overlying retinal vessels at lower IOP’s limited precise measurements of changes in ONH capillary perfusion compared to baseline. Therefore, OCT/OMAG can be a useful tool to image and measure blood flow in the retina, choroidal and ONH of the rat eye as well as document the effects of elevated IOP on blood flow in these vascular beds.

80 citations

Journal ArticleDOI
TL;DR: Despite asymmetrical reduction in SW thickness and function, MBF is preserved and MBF reserve is homogeneously reduced in LBBB patients with left ventricular systolic dysfunction, and the accuracy of SPECT for detecting CAD was significantly compromised compared with MCE in this patient cohort.
Abstract: Background— We aimed to investigate the cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) to ascertain the value of MCE for detecting coronary artery disease (CAD) and to uncover the mechanism that affects the accuracy of single-photon emission computed tomography (SPECT) in these patients. Methods and Results— Sixty-three symptomatic LBBB patients (group A), 10 left ventricular ejection fraction–matched control subjects without LBBB and no CAD (group B), and 10 normal control subjects (group C) underwent resting echocardiography. Rest and vasodilator MCE and SPECT were undertaken in LBBB patients. Septal (SW) and posterior wall (PW) thickness, thickening, quantitative myocardial blood flow (MBF), and MBF reserve were measured. SW/PW thickness and percentage thickening ratios were lower (P<0.01 and P<0.05, respectively) in group A compared with both groups B and C, but resting SW/PW MBF and MBF reserve ratios were similar in all 3 groups. MBF reserve but n...

80 citations


Network Information
Related Topics (5)
Magnetic resonance imaging
61K papers, 1.5M citations
88% related
Ejection fraction
47.6K papers, 1.6M citations
82% related
Coronary artery disease
77.6K papers, 2.2M citations
81% related
Ischemia
53.6K papers, 1.9M citations
80% related
Stroke
112.7K papers, 3.7M citations
80% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023181
2022372
2021394
2020362
2019407
2018336