Topic
Piper retrofractum
About: Piper retrofractum is a research topic. Over the lifetime, 126 publications have been published within this topic receiving 1216 citations.
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TL;DR: The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn and P. retrofractum were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml.
Abstract: The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml. Two lignans, cubebin and hinokinin, were isolated from the hexane extract of P. cubeba; and one bis-epoxy lignan, (−)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial activity of these two plants and their isolated constituents.
96 citations
Journal Article•
TL;DR: Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.) and the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae.
Abstract: Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3rd and 4th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid extract (002/3) in distilled water lost their larvicidal activity upon aging. Loss of activity at 25 degrees C was greater than that stored at 4 degrees C, and greater in water than in acetone solution.
94 citations
TL;DR: It is demonstrated that PRPAs attenuate HFD-induced obesity by activating AMPK and PPARδ, and regulate lipid metabolism, suggesting their potential anti-obesity effects.
93 citations
TL;DR: This paper provides ethnobotanical and botanical descriptions and illustrations of eight Piper species that are popularly used among Thai people as vegetables, spices, decoration and medicines and for traditional ceremonies.
Abstract: Thailand is located in the tropical rain forest zone above the equator. This geographically supports very rich biodiversity, including the genus Piper (Piperaceae). Thirty-eight species of Piper, from out of over 1,000 species in the world, have been discovered recently (1998-2006) by the authors. Plant morphology and plant use information were recorded via observation, market surveys, and interviews with traditional healers and local peoples. In this paper we provide ethnobotanical and botanical descriptions and illustrations of eight Piper species that are popularly used among Thai people as vegetables, spices, decoration and medicines and for traditional ceremonies. These species consist of P. betle L., P. longum L., P. nigrum L., P. pendulispicum C.DC., P. retrofractum Vahl, P. sarmentosum Roxb., P. wallichii (Miquel) Handel-Mazetti and a newly described Piper sp.
76 citations
01 Jan 2011
TL;DR: It is inferred that Cyperus rotundus, Plumbago zeylanica, Symplocos racemosa and Terminalia arjuna contain potential alpha-glucosidase inhibitors that can be exploited for its use in the treatment of diabetes.
Abstract: Alpha-glucosidase inhibitory activity of fifteen Indian medicinal plants has been evaluated by in vitro enzyme assay. Methanol extracts of Cyperus rotundus (tubers), Plumbago zeylanica (root), Symplocos racemosa (bark), and Terminalia arjuna (bark) had displayed 100% inhibition with the IC 50 value of 3.98 µg/ml, 3.46 µg/ml, 8.16 µg/ml and 0.69 µg/ml, respectively. Bark extract of Terminalia arjuna is highly effective against alpha- glucosidase activity even at nanogram concentration. Plant parts of Piper retrofractum (stem), Zingiber officinale (rhizome), Acorus calamus (rhizome), Picrorhiza kurroa (rhizome), Marsdenia tenacissima (stem), Clerodendron serratum (root), and Rubia cordifolia (root) are not effective and they require high concentration to exhibit inhibition. Potential plants that show maximum inhibition at low concentration (<10 µg/ml) were subjected to kinetic analysis to determine the mode of inhibition of the enzyme. Cyperus rotundus, Symplocos racemosa and Terminalia arjuna exhibited uncompetitive inhibition and Plumbago zeylanica had displayed mixed inhibition to alpha-glucosidase enzyme activity. From the enzyme assay, we infer that Cyperus rotundus, Plumbago zeylanica, Symplocos racemosa and Terminalia arjuna contain potential alpha-glucosidase inhibitors that can be exploited for its use in the treatment of diabetes.
74 citations