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About: Piperidine is a(n) research topic. Over the lifetime, 8893 publication(s) have been published within this topic receiving 87917 citation(s). The topic is also known as: cyclopentimine & cypentil.

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Journal ArticleDOI
David O'Hagan1

904 citations

Journal ArticleDOI

464 citations

Journal ArticleDOI
Abstract: This microreview focuses on recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids. The most recent examples are described, from simple piperidine alkaloids to complex pentacyclic structures such as (+)-tabersonine. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

378 citations

Journal ArticleDOI
Abstract: Functionalization of micelle-templated silica (MTS) was achieved by silanation of the MTS surface by 3-amino and 3-halogeno-propyl alkoxysilane in an apolar solvent. The grafted halogeno organic moieties were further modified by halogen substitution of other functions such as piperidine, tetraalkyl guanidine, (-)-ephedrine, 3-[N,N′-bis-3-salicyldenamino propylamine] (Salpr) and 3-[N,N′-bis-3-(3,5-di-tert-butylsalicyldenamino) propylamine] (tSalpr). During the modification procedure, the regular mesoporous structure of the MTS support was preserved. MTS-bound primary and tertiary amine functions were effective immobilized catalysts for Knoevenagel condensation and selective monoglyceride synthesis. MTS-bound 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was an efficient base catalyst for performing transesterification reaction. Chiral β-aminoalcohols such as (-)-ephedrine grafted on MTS allowed the catalysed alkylation of benzaldehyde by diethylzinc with high conversion and selectivity in 1-phenyl-propanol and moderate enantioselectivity in the (1R) enantiomorph. Manganese (III) Salpr and tSalpr complexes linked to the MTS surface catalysed styrene epoxidation using iodosylbenzene. The efficiency of this latter catalysis should be improved by the use of other liganding molecules more resistant than salen-type ligands towards oxidation media.

316 citations

Journal ArticleDOI
Abstract: The photocatalytic oxidation of a related series of primary, secondary, and tertiary amines and other nitrogen- and sulfur-containing organic compounds over a UV-illuminated film of TiO{sub 2} has been studied. The compounds were as follows: n-pentylamine, piperidine, pyridine, phenylalanine, desipramine, thioridazine, penicillamine, isosorbide dinitrate, 4-nitrocatechol, 2,4-dinitrophenol, cyclophosphamide, 5-fluorouracil, atrazine, ethylenediaminetetracetic acid, and tetrabutylammonium phosphate. Both ammonium and nitrate ions were formed. The relative concentration of the two ions depended on the nature of the nitrogen in a compound, but was also influenced by the illumination time and concentration of the solute. It was found that for n-pentylamine, piperidine and pyridine, the rate of formation of ammonium ions was n-pentylamine {much gt} pyridine > piperidine. The order of rates of nitrate formation was pyridine = piperidine {much gt} pentylamine. For n-pentylamine the rate of formation of ammonium ions was {approximately}100 times that of nitrate.

314 citations

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