Topic
Piperidine
About: Piperidine is a research topic. Over the lifetime, 8893 publications have been published within this topic receiving 87917 citations. The topic is also known as: cyclopentimine & cypentil.
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TL;DR: The reaction of 1-amino-4-acylaminoanthraquinones with piperidine in the presence of CoCl2 and atmospheric oxygen gave the 2-aminated products in 75-80%.
Abstract: The reaction of 1-amino-4-acylaminoanthraquinones with piperidine in the presence of CoCl2 and atmospheric oxygen gave the 2-aminated products in 75–80%, and similar reaction of 1-hydroxyanthraquinone or 1-aminoanthraquinone-2-sulfonic acid with butylamine gave the corresponding 4-aminated products, respectively. The effects of the α-substituents and the role of metal salts were discussed.
TL;DR: In this paper, a novel strategy for the enantioselective synthesis of polyhydroxypiperidines, which can be considered as iminoglycitols or 2,6-dideoxyazasugars, was developed.
Abstract: A novel strategy for the enantioselective synthesis of polyhydroxypiperidines, which can be considered as iminoglycitols or 2,6-dideoxyazasugars, was developed. α-Benzolsulfonylamino esters served as a C2N building block while 2-bromo-3-(bromomethyl)oxazoles and -thiazoles contributed a C3-unit to the final piperidine ring. At first a dihydropyridine ring was established via alkylation and bromine−lithium exchange. The keto group of the resulting 5,6-dihydro[1,3]oxazolo- and 5,6-dihydro[1,3]thiazolo[4,5-c]pyridin-7(4H)-ones was reduced and, after alkylation reactions, the azole ring was cleaved, thus providing heteroatom substituents for the target piperdines. Protected 5-amino-3,4-dihydroxy and 5-amino-3-hydroxy-4-thiohydroxypiperdines were obtained in the talose series while Mitsunobu reaction of the intermiediates provided access to the altrose series.
TL;DR: In this paper, an efficient and high yielding method for the synthesis of different densely functionalized piperidine derivatives via pseudo-five component, one-pot domino reaction through a combination of β-ketoesters, aromatic aldehydes, and various amines using p-sulfonic acid calix[n]arenes as catalysts.
Abstract: An efficient, suitable and high yielding method has been developed for the synthesis of different densely functionalized piperidine derivatives via pseudo-five component, one-pot domino reaction through a combination of β-ketoesters, aromatic aldehydes, and various amines using p-sulfonic acid calix[n]arenes as catalysts. The reaction was carried out in refluxing methanol, affording very good yields of the expected piperidine. Atomic economy, environmentally benign procedure, reuse of catalysts, and short reaction time are some of the important features of this protocol.
Patent•
24 Sep 1973
TL;DR: In this article, 9,10-phenanthraquinonimine is made to react with 5-substituted furfural, wherein H, Cl, Br, CHO, COCH 3, COOH may be used as substituents in the presence of piperidine in a medium of an organic solvent at the reaction mixture boiling temperature, whereupon said solvent is eliminated.
Abstract: Organic phosphors are essentially chemical compounds of the following structural formula ##SPC1## Where R = H, Cl, Br, CHO, COCH 3 , COOH, or ##SPC2## The method of preparing said substances resides in that 9,10-phenanthraquinonimine is made to react with 5-substituted furfural, wherein H, Cl, Br, CHO, COCH 3 , COOH may be used as substituents in the presence of piperidine in a medium of an organic solvent at the reaction mixture boiling temperature, whereupon said solvent is eliminated.
Patent•
27 Apr 2012TL;DR: In this paper, a selective dual modulator of the 5-HT 2A and D 3 receptors of formula (I) is described. But the present paper is concerned with the manufacture of the compounds of formula, pharmaceutical compositions comprising them and their use as pharmaceuticals.
Abstract: The present invention is concerned with novel selective dual modulators of the 5-HT 2A and D 3 receptors of formula (I)
wherein R 1 , R 2 , R 3 , n, and Y are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as pharmaceuticals.