Topic
Piperidine
About: Piperidine is a research topic. Over the lifetime, 8893 publications have been published within this topic receiving 87917 citations. The topic is also known as: cyclopentimine & cypentil.
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TL;DR: The intramolecular aza-Michael reaction of carbamates bearing remote alpha,beta-unsaturated aldehydes under organocatalytic conditions took place with good yields and excellent ee's when Jørgensen catalyst IV was used in the process, giving rise to the enantioselective formation of several five- and six-membered heterocycles.
156 citations
TL;DR: An efficient chiral Lewis acid-catalyzed inverse-electron-demand Diels−Alder reaction of 1-azadienes is described, providing highly functionalized piperidine derivatives in good yields with excellent endo-selectivity, and enantioselectivities typically in the range of 77−92% ee.
Abstract: An efficient chiral Lewis acid-catalyzed inverse-electron-demand Diels−Alder reaction of 1-azadienes is described. This procedure is based on the combination of NiII-DBFOX complex as catalyst and the use of a metal-coordinating (8-quinolyl)sulfonyl moiety at the iminic nitrogen of the N-sulfonyl 1-aza-1,3-diene, providing highly functionalized piperidine derivatives in good yields with excellent endo-selectivity, and enantioselectivities typically in the range of 77−92% ee.
154 citations
TL;DR: In this article, the adsorption and corrosion inhibition properties of three piperidine derivatives, namely, (1-(5-fluoro-2-(methylthio) pyrimidine-4-yl)-piperidine 4-yl), (1.5-5-dimethoxybenzenesulfonamide (FMPPDBS) and FMPPNBS, on the corrosion of iron were investigated by performing quantum chemical calculations and molecular dynamics simulations.
Abstract: The adsorption and corrosion inhibition properties of three piperidine derivatives namely, (1-(5-fluoro-2-(methylthio) pyrimidine-4-yl) piperidine-4-yl)-2,5-dimethoxybenzenesulfonamide (FMPPDBS), (1-(5-fluoro-2-(methylthio) pyrimidine-4-yl) piperidine-4-yl)-4-nitrobenzenesulfonamide (FMPPNBS), (1-(5-fluoro-2-(methylthio) pyrimidine-4-yl) piperidine-4-yl)-3-methoxybenzenesulfonamide (FMPPMBS) on the corrosion of iron were investigated by performing quantum chemical calculations and molecular dynamics simulations. Global reactivity parameters such as E HOMO , E LUMO , HOMO–LUMO energy gap (∆ E ), chemical hardness, softness, electronegativity, proton affinity, electrophilicity and nucleophilicity have been calculated and discussed. The adsorption behaviors of these piperidine derivatives on Fe(110), Fe(100) and Fe(111) surfaces were investigated using molecular dynamics simulation. The binding energies on metal surface of studied compounds followed the order: FMPPDBS > FMPPMBS> FMPPNBS and this ranking obtained is consistent with the experimental data.
152 citations
TL;DR: In this paper, crystal structure analyses of five crystalline enamines together with recently published structural data for two other enamines reveal varying degree of pyramidality at the enamine nitrogen atom.
Abstract: Crystal structure analyses of five crystalline enamines together with recently published structural data for two other enamines reveal varying degree of pyramidality at the enamine nitrogen atom. The pyramidality appears to be most pronounced in enamines from piperidine and morpholine, less so in enamines derived from prolinoid amines. A pyrolidine enamine obtained from a derivative of cyclohexane-1,4-dione seems to have a virtually planar enamine group. The implications of these findings for current stereochemical problems in enamine chemistry are discussed.
150 citations
TL;DR: Both reactions can be used in conjunction with other base specific modifications described by Maxam and Gilbert for the determination of the nucleotide sequence in DNA.
Abstract: Exposure of DNA to methylene blue and visible or ultraviolet light causes guanine-specific modification, and subsequent treatment with piperidine leads to chain cleavage at each guanine residue. Treatment of DNA with osmium tetraoxide in dilute pyridine leads to thymidine-specific modification, and subsequent treatment with piperidine leads to chain cleavage at the modified thymidine residues. Both reactions can be used in conjunction with other base specific modifications described by Maxam and Gilbert (1) for the determination of the nucleotide sequence in DNA.
148 citations