Showing papers on "Piperlonguminine published in 2018"
TL;DR: The fruit extracts of P. nigrum and P. longum had both acaricidal and oviposition limiting actions against the adults of R. (B.) microplus which could make it a valuable component of developing sustainable strategy for integrated tick management.
Abstract: In vitro acaricidal activity of Piper nigrum and P longum fruit extracts and their active components (piperine for P nigrum and piperine and piperlonguminine for P longum) was evaluated against adults engorged females of Rhipicephalus (Boophilus) microplus using adult immersion test Three concentrations of each extract with four replications were used in the bioassay Extracts significantly affected mortality rates of ticks in dose-dependent manner ranged 125–958% for P nigrum and 292–875% for P longum, with an additional effect on the reproductive physiology of ticks by inhibiting oviposition (281–969% by P nigrum and 361–893% by P longum) However, the acaricidal and oviposition limiting properties were decreased significantly when the active component(s) of each extract was tested separately However, the combination of piperine and piperlonguminine (obtained from P longum extract) caused 792% mortality of ticks which is equivalent to the corresponding concentration (~ 5%) of the extract It can be concluded that the fruit extracts of P nigrum and P longum had both acaricidal and oviposition limiting actions against the adults of R (B) microplus which could make it a valuable component of developing sustainable strategy for integrated tick management
20 citations
TL;DR: Results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.
Abstract: Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activity. The extracts, with the exception of the hot water decoctions and macerations, contained piperamide alkaloids as their main constituents. Piperine, dihydropiperine, piperylin, dihydropiperylin or piperlonguminine, dihydropiperlonguminine, wisanine, dihydrowisanine and derivatives of piperine and piperidine were identified in a hexane extract of the leaf. In addition, some new piperamide alkaloids were identified, such as a piperine and a piperidine alkaloid derivative and two unknown piperamide alkaloids. To the best of our knowledge, there are no piperamides reported in the literature with similar UVλ absorption maxima and masses. A piperamide alkaloid-rich hexane leaf extract recorded the lowest MIC of 19 µg/mL against Sarcina sp. and gave promising growth inhibitory effects against S. aureus and E. aerogenes as well, inhibiting the growth of both bacteria with a MIC of 78 µg/mL. Moreover, this is the first report of the antibacterial activity of P. guineense extracts against Sarcina sp. and E. aerogenes. Marked growth inhibition was also obtained for chloroform extracts of the leaves and fruits against P. aeruginosa with a MIC value of 78 µg/mL. Piperine and piperlongumine were active against E. aerogenes, S. aureus, E. coli, S. enterica, P. mirabilis and B. cereus with MIC values ranging from 39⁻1250 µg/mL. Notably, the water extracts, which were almost devoid of piperamide alkaloids, were not active against the bacterial strains. Our results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.
15 citations