Topic
Piperlonguminine
About: Piperlonguminine is a research topic. Over the lifetime, 106 publications have been published within this topic receiving 3046 citations.
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TL;DR: Eight compounds obtained from the dry fruits of Piper longum L., and their potential vascular relaxant activities were explored, revealed the access of Rosin and Piperchabaoside, and Piperine was observed to promote the influx of extracellular calcium in MASMCs, and via an endothelium-independent mechanism involving Ca2+ entry.
11 citations
TL;DR: A phytochemical investigation of the roots and stems of Piper sylvaticum (Roxb) resulted in the isolation and identification of piperine, piperlonguminine, N-isobutyldeca-trans-2- trans-4-dienamide, and β-sitosterol.
11 citations
TL;DR: In this paper, the naturally occurring dienamides, including piperine, piperlonguminine, guineensine, brachystamide-B and pergumidiene, were converted to β, γ-unsaturated amides by using Zn HOAc.
11 citations
TL;DR: Results indicate that PL could be a candidate therapeutic agent for various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
Abstract: The nuclear DNA binding protein known as high-mobility group box 1 (HMGB1) acts as a late mediator of severe vascular inflammatory conditions, such as sepsis and septic shock. Piperlonguminine (PL), an important component of Piper longum fruit, is known to exhibit anti-hyperlipidemic, anti-platelet, and anti-melanogenesis activities. However, little is known about its effects on HMGB1-mediated inflammatory response. We investigated the effects of PL on HMGB1-mediated inflammatory response by monitoring the effects of PL on lipopolysaccharide or cecal ligation and puncture (CLP)-mediated release of HMGB1, as well as on the modulation of HMGB1-mediated inflammatory responses. According to our data, PL caused inhibition of the release of HMGB1 and downregulation of HMGB1-dependent inflammatory responses in human endothelial cells. PL also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice. In addition, treatment with PL reduced the CLP-induced release of HMGB1 and sepsis-related mortality. These results indicate that PL could be a candidate therapeutic agent for various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
11 citations
TL;DR: In this paper, an ultra-high-performance supercritical fluid chromatography (UHPSFC)-MS method was applied to simultaneously determine 9 characteristic constituents (piperine, piperlonguminine and piperanine), pipercallosine, dehydropipernonaline, pernnonatine, retrofractamide B, pellitorine and guineensine).
10 citations