Topic
Piperlonguminine
About: Piperlonguminine is a research topic. Over the lifetime, 106 publications have been published within this topic receiving 3046 citations.
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TL;DR: Results indicate that the amide fractions piperovatine and piperlonguminine showed the greatest inhibitory activity of topical inflammation induced by croton oil.
50 citations
TL;DR: Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds, methylpiperate, guineensine, and piperlonguminine, which further expanded on the identification of MAO inhibitors from the fruit of P. longum.
Abstract: We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of P. longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds, methylpiperate (1), guineensine (2), and piperlonguminine (3). Of these, methylpiperate (1) and guineensine (2) showed significant MAO inhibitory activities with IC50 values of 3.6 and 139.2 μM, respectively. Furthermore, methylpiperate (1) exhibited a selective inhibitory effect against MAO-B (IC50 value: 1.6 μM) than MAO-A (IC50 value: 27.1 μM). The kinetic study using the Lineweaver-Burk plots analysis suggested that methylpiperate (1) competitively inhibits MAO-A and MAO-B activities with the Ki values of 23.5 and 1.3 μM, respectively.
50 citations
TL;DR: A simple, effective and suitable UFLC-ESI-MS/MS method was firstly developed to simultaneously determine five characteristic constituents of Piper longum L. longum, which had lower piperine content but was enriched in the other four alkaloids.
45 citations
TL;DR: The UFLC-ESI-MS/MS method was successfully applied to pharmacokinetic studies of piperine and piperlonguminine in rats after oral administration of alkaloids from P. longum L. showed protective effects on Parkinson's disease models in the authors' previous study.
44 citations
TL;DR: From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmanseggiamide A and hoffsmannseGGiamide B, were obtained together with the known compounds isopiperlonguminine and isocorcovadine, sitosterol, and stigmasterol.
Abstract: Chromatographic fractionation of a dichloromethane extract from the leaves of Piper scutifolium yielded two new isobutyl amides, scutifoliamide A (1) and scutifoliamide B (2), together with the known compounds piperolactam C (3), piperovatine (4), piperlonguminine (5), corcovadine (6), isopiperlonguminine (7), and isocorcovadine (8). From the dichloromethane extract from the leaves of P. hoffmannseggianum two new isobutyl amides, hoffmannseggiamide A (9) and hoffmannseggiamide B (10), were obtained together with the known compounds isopiperlonguminine (7) and isocorcovadine (8), sitosterol, and stigmasterol. The structures of the new compounds were established on the basis of spectroscopic data analysis. The inhibitory activity of compounds 1−10 against the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides was determined by bioautography.
43 citations