Topic
Piperlonguminine
About: Piperlonguminine is a research topic. Over the lifetime, 106 publications have been published within this topic receiving 3046 citations.
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TL;DR: In this article, a regioselective reduction of the α, β - double bond of the naturally occurring dienamides, piperine and piperlonguminine was achieved by using NaBH 4 I 2 system.
18 citations
Journal Article•
TL;DR: The present study aimed to extract the phytochemical compounds in different solvent system in Piper longum, Piper nigrum and Piper cubeba as well as testing their antibacterial and antitumour activity.
18 citations
Journal Article•
TL;DR: In this paper, the authors assessed the biological activity of a crude extract, a mixture of several fractions, and a pure compound obtained from Piper ovatum Vahl against promastigote and amastigotes forms of Leishmania amazonensis.
Abstract: We assessed the biological activity of a crude extract, a mixture of several fractions, and a pure compound obtained from Piper ovatum Vahl against promastigote and amastigote forms of Leishmania amazonensis . The medicinal plant P. ovatum is used popularly as an anesthetic and anti-inflammatory. This study included the extraction process and bioassay-guided fractionation by the adsorption chromatography and Sephadex LH-20 method. A progressive increase in the antileishmanial effect was observed in the course of fractionation. The 50% inhibitory concentration (IC50) for dichloromethane-ethyl acetate (1:1 v/v) fraction was 2.1 μg/ml and 24 μg/ml; mixture of piperovatine: piperlongumune (2:3) 0.9 μg/ml and 24 μg/ml; piperovatine (1) 9.5 μg/ml and 10 μg/ml; and piperlonguminine (2) 2.5 μg/ml and 9.0 μg/ml, for promastigote and amastigote forms, respectively. Cytotoxicity analysis indicated that these toxic concentrations were much higher for J774G8 macrophages and Vero cells than for the protozoans. The mixture of piperovatine: piperlongumune (2:3) showed important antiprotozoal activity against the amastigote and promastigote forms of L. amazonensis , and it produced morphological changes in promastigotes and amastigotes at 0.9 μg/ml and 24 μg/ml (50% growth inhibition concentration), respectively, including intense cytoplasmic vacuolization, mitochondrial swelling, and mitochondrial damage, as revealed by transmission electron microscopy.
18 citations
TL;DR: Data show that PE protects the brain against ischemic cerebral injury via alleviating blood-brain barrier (BBB) breakdown, which may be mediated via inhibiting NF-κB and MAPK signaling pathways.
17 citations
TL;DR: P. chaba may be a potential source of plant-based therapeutic lead compounds, which justify its uses in traditional medicine.
17 citations