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PL/C

About: PL/C is a research topic. Over the lifetime, 18 publications have been published within this topic receiving 258 citations.

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01 Jan 2011
TL;DR: Since treatment for AML differs from that for APL, identification of the 15;17 translocation and ultrastructural evidence of granules represent valuable diagnostic aids forAPL.
Abstract: Cytogenetic and ultrastructural findings were important diagnostic indicators of hypergranular promyelocytic leukemia (APL) in a patient whose bone marrow morphology appeared, by light microscopy, to be similar to that in acute myeloblastic leukemia (AML) with maturation. Peripheral blood smears and bone marrow specimens examined by light microscopy showed few cells with the numerous coarse, azurophilic granules typical of APL. Cytogenetic analyses, with several banding techniques, of cells from bone marrow and unstimulated peripheral blood revealed the 15;17 translocation, which has been observed only in APL. A reinterpretation of the reciprocal translocation, based on R banding, suggests that the breakpoints are distal to q24 in No. 15 and at or near the junction of q21 and q22 in No. 17. In addition, the patient had disseminated intravascular coagulation. The characteristic morphology of granules seen in APL was observed in this case only when transmission electron microscopy was used, since the granules were quite small. Since treatment for AML differs from that for APL, identification of the 15;17 translocation and ultrastructural evidence of granules represent valuable diagnostic aids for APL.

57 citations

Journal ArticleDOI
TL;DR: Results indicate that the Gp-regulated PL C in GH3 cell membranes is an extrinsic membrane protein that can be extracted reversibly at high ionic strength and can be distinguished from cytosolic PL C isoenzymes.

19 citations

Journal ArticleDOI
TL;DR: Carnitine deficiency and oxidative stress, secondary to Fanconi Syndrome, constitute risk factors and should be viewed as mechanisms during development of IFO-induced cardiotoxicity, and PLC supplementation completely reversed the biochemical changes-induced by IFO to the control values.
Abstract: th and 6 th groups were injected with the same doses of normal saline, DC-MD and pL C, respectively for 5 successive days before and 5 days concomitant with IFO (50 mg/kg/day). IFO significantly increased serum creatinine, blood urea nitrogen (BUN), urinary carnitine excretion and clearance, creatine phosphokinase isoenzyme (CK-MB), lactate dehydrogenase (LD h) , intramitochondrial acetyl-CoA/ CoA-s h and thiobarbituric acid reactive substances (TBAR s) i n cardiac tissues and significantly decreased adenosine triphosphate (AT p) and total carnitine and reduced glutathione (Gsh) content in cardiac tissues. In carnitine-depleted rats, IFO induced dramatic increase in serum creatinine, BUN, CK-MB, LD h, carnitine clearance and intramitochondrial acetyl-CoA/CoA-s h, a s well as progressive reduction in total carnitine and AT p in cardiac tissues. Interestingly, pL C supplementation completely reversed the biochemical changes-induced by IFO to the control values. In conclusion, data from the present study suggest that: Carnitine deficiency and oxidative stress, secondary to Fanconi sy ndrome, constitute risk factors and should be viewed as mechanisms during development of IFO-induced cardiotoxicity. Carnitine supplementation, using pL C, prevents the development of IFO-induced cardiotoxicity through antioxidant signalling and improving mitochondrial function.

16 citations

Journal ArticleDOI
TL;DR: The results suggest that GnRH may affect the growth of mammary tumors directly and not only through the reduction of blood gonadotropin level.

14 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20111
20101
20001
19901
19891
19871