Topic
Placental alkaline phosphatase
About: Placental alkaline phosphatase is a research topic. Over the lifetime, 1056 publications have been published within this topic receiving 30423 citations. The topic is also known as: PALP & PLAP.
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TL;DR: Binding was not detected on 3T3 fibroblasts carrying the steel (Sl) mutation, confirming the biological significance of the binding activity and demonstrating that mutations at the Sl locus affect the expression or structure of the kit ligand.
799 citations
TL;DR: In transient expression experiments using transfected mammalian cells, it is demonstrated that SEAP yields results that are qualitatively and quantitatively similar, at both the mRNA and protein levels, to parallel results obtained using established reporter genes.
681 citations
TL;DR: This review tried to provide an overview about the various forms, structure and functions of alkaline phosphatase with special focus on liver/bone/kidney alkalineosphatase.
Abstract: Alkaline phosphatase (ALP; E.C.3.I.3.1.) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values. Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP. The intestinal and placental ALP loci are located near the end of long arm of chromosome 2 and L/B/K ALP is located near the end of the short arm of chromosome 1. Although ALPs are present in many mammalian tissues and have been studied for the last several years still little is known about them. The bone isoenzyme may be involved in mammalian bone calcification and the intestinal isoenzyme is thought to play a role in the transport of phosphate into epithelial cells of the intestine. In this review, we tried to provide an overview about the various forms, structure and functions of alkaline phosphatase with special focus on liver/bone/kidney alkaline phosphatase.
558 citations
TL;DR: In this article, the authors described the characterization of the human liver/bone/kidney alkaline phosphatase locus, which appears to exist as a single copy in the haploid genome and is comprised of 12 exons distributed over more than 50 kilobases.
370 citations
Journal Article•
TL;DR: The possibility that elevated serum alkaline phosphatase in patients with metastatic cancer can be of neoplastic rather than of hepatic and osseous origin is demonstrated.
Abstract: Summary In the course of a study of serum phosphatase isoenzymes in cancer patients, a patient with bronchogenic carcinoma was discovered, whose serum contained an alkaline phosphatase which was indistinguishable from placental alkaline phosphatase. The same enzyme was demonstrated in high concentration in the neoplasm and its metastases. This single case demonstrates the possibility that elevated serum alkaline phosphatase in patients with metastatic cancer can be of neoplastic rather than of hepatic and osseous origin.
344 citations