Topic
Platinum
About: Platinum is a research topic. Over the lifetime, 49675 publications have been published within this topic receiving 1150035 citations. The topic is also known as: Pt & element 78.
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TL;DR: In this article, a comparative study was performed to determine the reactivity of nitrate ions at 0.1 M on eight polycrystalline electrodes (platinum, palladium, rhodium, ruthenium, iridium, copper, silver and gold) in acidic solution using cyclic voltammetry (CV), chronoamperometry and differential electrochemical mass spectroscopy (DEMS).
435 citations
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01 Jan 1991
TL;DR: The resistant cells repair interstrand crosslinks more efficiently than the sensitive ones from the DHFR gene, the multidrug resistance gene and from the inactive oglobin gene, however, these ovarian cancer cell lines do not differ in their ability to repair cisplatin intrastrand adducts from these genes.
Abstract: By Vilhelm A. Bohr, Eddie Reed*) and Wei ping Zhen Laboratory of Molecular Pharmacology and *)Medicine Branch, National Cancer Institute, Bldg. 37 Rm 5C-25, NIH, Bethesda, MD 20892 We have developed techniques to study the DNA damage formation and repair of cisplatin lesions in individual genes. The frequency of intrastrand adducts and interstrand crosslinks can be determined in restriction fragments within genes or in non-transcribed gene regions. In hamster cells, intrastrand adducts are repaired faster from the essential dihydrofolate reductase (DHFR) gene than from an inactive region. In contrast, interstrand crosslinks are repaired at a similar rate from the active and inactive genomic regions. In an attempt to study the role of DNA repair in drug resistance, we have examined the repair of these lesions in certain important genes in cisplatin sensitive and resistant human ovarian cancer cells. The resistant cells repair interstrand crosslinks more efficiently than the sensitive ones from the DHFR gene, the multidrug resistance gene and from the inactive oglobin gene. However, these ovarian cancer cell lines do not differ in their ability to repair cisplatin intrastrand adducts from these genes.
435 citations
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TL;DR: This work reports a system based on palladium icosahedra that demonstrates an effective approach to the development of electrocatalysts with greatly enhanced activity and durability.
Abstract: Core-shell catalysts can enhance activity while reducing the loading of expensive catalyst materials. Here, the authors report a palladium@platinum system in which the platinum shells evolve into a corrugated structure with compressive strains, with subsequent enhancement of oxygen reduction activity.
434 citations
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TL;DR: An environmentally friendly method using the metal ion-reducing bacterium Shewanella algae was proposed to deposit platinum nanoparticles to reduce aqueous PtCl(6)(2-) ions into elemental platinum at room temperature and neutral pH within 60min when lactate was provided as the electron donor.
433 citations
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TL;DR: Oxygen reduction was found to be sensitive to the crystallographic orientation of the platinum electrode surface as discussed by the authors, and a special cleaning procedure has been developed to remove impurities from the surface prior to the oxygen reduction measurements.
430 citations