Topic
Polarography
About: Polarography is a research topic. Over the lifetime, 4772 publications have been published within this topic receiving 75478 citations.
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TL;DR: In this paper, a new method of speciation by differential pulse polarography (DPP) is described, which is focused on non-labile complexes on the DPP time scale.
29 citations
29 citations
TL;DR: In this article, a very well resolved diffusion controlled differential pulse polarographic peak obtained at pH 7 was used to develop a new method for the determination of nimesulide in pharmaceutical dosage forms and the recovery study (104.8% with a RSD of 1.3%) showed that the method is sufficiently accurate and precise to be applied in the individual tablet assay of commercial samples.
Abstract: Nimesulide, N-(4-nitro-2-phenoxyphenyl)methanesulfonamide is an antiinflamatory analgesic agent that is both reducible at the mercury electrode and oxidizable at the glassy carbon electrode. Nimesulide in hydroalcoholic solution, presents cathodic response in a wide range of pH (2–12), both, by differential pulse and tast polarography techniques. The obtained results show only one main well-defined peak or wave in all the pH range studied. This peak (or wave) corresponds to the nitro group reduction in position 4. The voltammetric oxidation shows one well-resolved signal in all the pH range studied. This anodic signal could be attributed to the methylsulfonamide group oxidation. For analytical purposes, a very well resolved diffusion controlled differential pulse polarographic peak obtained at pH 7 was selected. This peak was used to develop a new method for the determination of nimesulide in pharmaceutical dosage forms. The recovery study (104.8% with a RSD of 1.3%) shows that the method is sufficiently accurate and precise to be applied in the individual tablet assay of commercial samples.
29 citations
29 citations
TL;DR: In this article, a general mechanism for the reduction process in alkaline and acid media is suggested, which includes a rate-determining step involving one electron, and different kinetic parameters for the electrode reaction support the suggested mechanism.
29 citations