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Polarography
About: Polarography is a research topic. Over the lifetime, 4772 publications have been published within this topic receiving 75478 citations.
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29 citations
TL;DR: In this article, an electrochemical study using differential pulse polarization (DPP) was performed to compare the behavior of metallothioneins and that of this less complex molecule.
Abstract: An electrochemical study, using differential pulse polarography (DPP), of a peptide Lys–Cys–Thr–Cys–Cys–Ala Thionein Fragment [56–61] MT I (FT) was performed in order to compare the behavior of metallothioneins and that of this less complex molecule, intrinsic to the metallothionein structure. The influence of different parameters, such as the solution pH and the concentration of metal elements, cadmium and zinc was investigated. Two different electrochemical systems were distinguished: in the first one, the mercury electrode itself is involved in the charge transfer steps; in this case, peaks are attributed to the oxidation of the mercury electrode in the presence of the peptide acting as a chelating agent. The second electrochemical system corresponds to the reduction of metal cations, cadmium and zinc, at a dropping mercury electrode either as free ions or complexed by the peptide. The apparent stability constants for complexes of FT with cadmium, zinc and mercury were estimated. The order of affinity is: K′HgFT ≫ K′CdFT > K′ZnFT. The DPP response can be used for elucidation of the chemical forms of compounds (speciation).
29 citations
TL;DR: The proposed method was successfully applied to the analysis of the two drugs in their commercial capsules, and the advantages of the method were time saving and more sensitive than the other published voltammetric method.
29 citations
TL;DR: In this paper, an electroanalytical study of timolol in the Britton-Robinson buffer is described and the dependence of the peak current on concentration is studied by means of different polarographic and voltammetric techniques.
29 citations
TL;DR: In this article, a simple d.c. polarographic method has been developed for the determination of metronidazole in dosages forms, which produces a well defined 4-electron polarographic wave followed by another wave of about half the height of the first wave.
Abstract: A simple d.c. polarographic method has been developed for the determination of metronidazole in dosages forms. In Robinson - Britton buffer (pH 4.38) and in presence of 1.60 × 10−3 % Triton X-100, the drug produced a well defined 4-electron polarographic wave followed by another wave of about half the height of the first wave. The current is proportional to the concentration and permits the drug to be determined by d.c. polarography in the concentration range 5.0 × 10−5 -7.0 × 10−4 M. Results obtained by the proposed method are in excellent agreement with that provided by the USP-XX method. A rapid, sensitive and accurate polarographic method for the determination of metronidazole in the tablets which are produced locally is proposed.
29 citations