Topic
Polygonum
About: Polygonum is a research topic. Over the lifetime, 1230 publications have been published within this topic receiving 12765 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: Three potential biomarkers and one criterion for potential liver injury caused by PM that may be more sensitive than ALT and AST were found.
Abstract: Abstract Context Polygonum multiflorum Thunb. (Polygonaceae) (PM) can cause potential liver injury which is typical in traditional Chinese medicines (TCMs)-induced hepatotoxicity. The mechanism involved are unclear and there are no sensitive evaluation indicators. Objective To assess PM-induced liver injury, identify sensitive assessment indicators, and screen for new biomarkers using sphingolipidomics. Materials and methods Male Sprague–Dawley (SD) rats were randomly divided into four groups (control, model with low-, middle- and high-dose groups, n = 6 each). Rats in the three model groups were given different doses of PM (i.g., low/middle/high dose, 2.7/8.1/16.2 g/kg) for four months. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the plasma and liver were quantitatively analyzed. Fixed liver tissue sections were stained with haematoxylin and eosin and examined under a light microscope. The targeted sphingolipidomic analysis of plasma was performed using high-performance liquid chromatography tandem mass spectrometry. Results The maximal tolerable dose (MTD) of PM administered intragastrically to mice was 51 g/kg. Sphingolipid profiling of normal and PM-induced liver injury SD rats revealed three potential biomarkers: ceramide (Cer) (d18:1/24:1), dihydroceramide (d18:1/18:0)-1-phosphate (dhCer (d18:1/18:0)-1P) and Cer (d18:1/26:1), at 867.3–1349, 383.4–1527, and 540.5–658.7 ng/mL, respectively. A criterion for the ratio of Cer (d18:1/24:1) and Cer (d18:1/26:1) was suggested and verified, with a normal range of 1.343–2.368 (with 95% confidence interval) in plasma. Conclusions Three potential biomarkers and one criterion for potential liver injury caused by PM that may be more sensitive than ALT and AST were found.
3 citations
Journal Article•
TL;DR: In this article, the chemical constitients of Polygonum cuspidatum were studied through column chromatography and their structures were elucidated through physicochemical and spectral analyses, and seven compounds were obtained from the diethyl ether fraction of ethanol extract.
Abstract: Objective To study the chemical constitients of Polygonum cuspidatum.Methods The compounds were isolated through column chromatography and their structures were elucidated through physicochemical and spectral analyses.Results Seven compounds were obtained from the diethyl ether fraction of ethanol extract and identified as physcion(Ⅰ),emodin(Ⅱ),ambrettolide(Ⅲ),β-sitosterol(Ⅳ),oleanolic acid(Ⅴ),coumarin(Ⅵ),and 2-ethoxy-8-acetyl-1,4-naphthoquinone(Ⅶ).Conclusion Compound Ⅶ is a new compound named as cuspidatumin A,and compound Ⅲ is obtained from P.cuspidatum for the first time.
3 citations
Patent•
23 Dec 2015
TL;DR: In this article, a preparation method of organic polygonum cupidatum acid is described, which is simple and low in condition requirement, no chemical agent is added in the preparation process, only the polygonal leaves and stems and pollution-free mountain spring water or purified water are adopted for fermentation to obtain the organic pectin acid, the prepared acid liquor serves as an organic and original product, the production process is conducted all in an organic, original mode, and residues, sewage discharge and environmental pollution caused by sewage do not exist.
Abstract: The invention discloses a preparation method of organic polygonum cupidatum acid. The method comprises the steps that cut fresh polygonum cupidatum leaves and stems are cleaned and put into a specially-made acid pool, the processes of water addition, sealing, fermentation, filtration, secondary fermentation and secondary filtration are conducted, and the organic polygonum cuspidatum acid which serves as main key organic acid liquor for preparing various organic phosphatic fertilizer and organic compound fertilizer is finally obtained. The preparation method of the organic polygonum cupidatum acid is simple and low in condition requirement, no chemical agent is added in the preparation process, only the polygonum cupidatum leaves and stems and pollution-free mountain spring water or purified water are adopted for fermentation to obtain the organic polygonum cupidatum acid, the prepared acid liquor serves as an organic and original product, the production process is conducted all in an organic and original mode, and residues, sewage discharge and environmental pollution caused by sewage do not exist.
3 citations
Patent•
21 May 2014
3 citations
Patent•
02 Dec 2015
TL;DR: In this paper, a polygonum multiflorum processing method is presented, which comprises the steps of cutting, slicing, and steaming. But the method is not suitable for the use in the food industry.
Abstract: The invention discloses a polygonum multiflorum processing method. The method comprises the steps of A, conducting cutting, wherein polygonum multiflorum is cut into 1 cm thick slices to form polygonum multiflorum slices; B, conducting soaking, wherein the polygonum multiflorum slices are soaked in saline water, taken out to be placed in black rice juice to be soaked, and then taken out to form soaked polygonum multiflorum slices; C, conducting steaming, wherein the soaked polygonum multiflorum slices are steamed with black soya bean juice to form steamed polygonum multiflorum slices; D, conducting inoculation, wherein lactic acid bacteria are inoculated on the steamed polygonum multiflorum slices, and then fermentation is conducted for 48 h; E, conducting drying for 2 h at the temperature of 45 DEG C; F, conducting detection and bagging so that a finished product can be obtained. By the adoption of the method, the polygonum multiflorum product which is good in taste, low in tannin content and high in free anthraquinone constituent content is obtained.
3 citations