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Polygonum
About: Polygonum is a research topic. Over the lifetime, 1230 publications have been published within this topic receiving 12765 citations.
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TL;DR: Findings suggest that aqueous extract of Polygonum minus possesses potent anti-inflammatory activities.
Abstract: The study was aimed to evaluate the anti-inflammatory activity of ethanolic and aqueous extracts of Polygonum minus (Huds) using in vitro and in vivo approaches. The in vitro tests used to evaluate ethanolic extract are cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), lipooxygenase (5-LOX), secretory phospholipase-A2 (sPLA2) inhibition assay whilst the in-vivo effect was measured by the ability of aqueous extracts to reduce paw edema induced by λ-carrageenan, in rats. The ethanolic extract inhibited the activities of 5-LOX and COX-1(p < 0.05) whilst the inhibitory effect on COX-2 was only moderate. A marked inhibition of 5-LOX was observed at 30 μg/ ml. The extract did not inhibit the activity of sPLA2. The ability of the ethanolic extracts of Polygonum minus to inhibit both 5-LOX and COX, prompted a study to evaluate the effects of using an aqueous extract of Polygonum minus ( LineminusTM); as this would be more suitable for future clinical testing. The anti-inhibitory activity of the aqueous extract from this plant was evaluated using a rat model where inflammation was induced in the paws by injection of λ-carrageenan. The aqueous extracts from Polygonum minus administered at doses of 100 and 300 mg/kg body weight (b.w.), significantly (p < 0.01) reduced paw edema induced by λ-carrageenan in the experimental model, at 4 h compared to the vehicle control. Furthermore, administration of 100 mg/kg b.w. or 300 mg/kg b.w. completely reduced inflammation of the paw 4 h after injection. These findings suggest that aqueous extract of Polygonum minus possesses potent anti-inflammatory activities.
43 citations
TL;DR: Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb and strongly inhibited the growth of human colon cancer cells.
42 citations
TL;DR: None of the results indicated intraspecific differences with altitude in P. weyrichii var.
Abstract: The timing of seedling emergence crucially affects the fate of seedlings. Germination characteristics are therefore an important factor determining plant distribution. The aim of this study is to examine whether two species of Polygonum show different germination characteristics in relation to their altitudinal distributions (P. cuspidatum: lowland to alpine; P. weyrichii var. alpinum: mainly alpine and with a higher upper altitudinal limit than P. cuspidatum). The seeds of both species freshly collected in autumn required high temperature (350C) for germination. After winter, seeds of both species showed high germinability over a wide temperature range and the optimum temperature shifted to 20 to 250C. Response to storage differed between the two species. All the storage conditions examined (moist chilling, dry chilling and dry warm) were effective in breaking seed dormancy of P. cuspidatum, but seed dormancy of P. weyrichii var. alpinum was broken only by moist chilling. The germination at a low temperature (50C) after the winter was significantly higher in P. weyrichii var. alpinum than in P. cuspidatum. In contrast to these interspecific differences, none of our results indicated intraspecific differences with altitude in P. cuspidatum.
42 citations
31 Mar 2022
TL;DR: Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants, molds, and lichens and has been used as a traditional medication for more than 2000 years and is still common in numerous herbal drugs as discussed by the authors .
Abstract: Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants, molds, and lichens. Emodin has been used as a traditional medication for more than 2000 years and is still common in numerous herbal drugs. Emodin is plentiful in the three plant families, including Polygonaceae (Rheum, Rumex, and Polygonum spp.), Fabaceae (Cassia spp.), and Rhamnaceae (Rhamnus, Frangula, and Ventilago spp.). Emerging experimental evidences indicate that emodin confers a wide range of pharmacological activities; special focus was implemented toward neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, anxiety and depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical evidences were established in support of the neuroprotection of emodin. However, this review highlighted the role of emodin as a potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).
42 citations
TL;DR: The clear zone of inhibition produced by the dichloromethane and methanol antifungal extracts of Xanthium spinosum could be ascribed to the fact that these extracts have another effect on fungal cells in addition to inhibition of cell walls.
41 citations